Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative

Eckstein F, Boudreau R, Wang Z, Hannon MJ, Duryea J, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK (2016)

Publication Type: Journal article

Publication year: 2016

Journal

European Radiology Springer Verlag (Germany)

Book Volume: 26

Pages Range: 1942-51

Journal Issue: 6

DOI: 10.1007/s00330-015-3977-8

Abstract

To evaluate whether change in fixed-location measures of radiographic joint space width (JSW) and cartilage thickness by MRI predict knee replacement.Knees replaced between 36 and 60 months' follow-up in the Osteoarthritis Initiative were each matched with one control by age, sex and radiographic status. Radiographic JSW was determined from fixed flexion radiographs and subregional femorotibial cartilage thickness from 3 T MRI. Changes between the annual visit before replacement (T0) and 2 years before T0 (T-2) were compared using conditional logistic regression.One hundred and nineteen knees from 102 participants (55.5 % women; age 64.2 ± 8.7 [mean ± SD] years) were studied. Fixed-location JSW change at 22.5 % from medial to lateral differed more between replaced and control knees (case-control [cc] OR = 1.57; 95 % CI: 1.23-2.01) than minimum medial JSW change (ccOR = 1.38; 95 % CI: 1.11-1.71). Medial femorotibial cartilage loss displayed discrimination similar to minimum JSW, and central tibial cartilage loss similar to fixed-location JSW. Location-independent thinning and thickening scores were elevated prior to knee replacement.Discrimination of structural progression between knee pre-placement cases versus controls was stronger for fixed-location than minimum radiographic JSW. MRI displayed similar discrimination to radiography and suggested greater simultaneous cartilage thickening and loss prior to knee replacement.o Fixed-location JSW predicts surgical knee replacement more strongly than minimum JSW. o MRI predicts knee replacement with similar accuracy to radiographic JSW. o MRI reveals greater cartilage thinning and thickening prior to knee replacement.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

University of California San Francisco (UCSF) US United States (USA) (US) Novartis AG CH Switzerland (CH) Merck KGaA DE Germany (DE) Northwestern University US United States (USA) (US) University of Sydney (USYD) AU Australia (AU) University of Arizona US United States (USA) (US) Paracelsus Medizinische Privatuniversität AT Austria (AT) University of Pittsburgh US United States (USA) (US) Harvard University US United States (USA) (US) Boston University US United States (USA) (US)

How to cite

APA:

Eckstein, F., Boudreau, R., Wang, Z., Hannon, M.J., Duryea, J., Wirth, W.,... Kwoh, C.K. (2016). Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative. European Radiology, 26(6), 1942-51. https://doi.org/10.1007/s00330-015-3977-8

MLA:

Eckstein, Felix, et al. "Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative." European Radiology 26.6 (2016): 1942-51.

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