Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival
Song J, Lokmic Z, Laemmermann T, Rolf J, Wu C, Zhang X, Hallmann R, Hannocks MJ, Horn N, Ruegg MA, Sonnenberg A, Georges-Labouesse E, Winkler T, Kearney JF, Cardell S, Sorokin L (2013)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2013
Journal
Book Volume: 110
Journal Issue: 31
Abstract
We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate. © PNAS 2013.
Authors with CRIS profile
Involved external institutions
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
University of Alabama at Birmingham (UAB)
United States (USA) (US)
Institute of Genetics and Molecular and Cellular Biology / Institut de génétique et de biologie moléculaire et cellulaire (IGBMC)
France (FR)
Netherlands Cancer Institute (NKI)
Netherlands (NL)
Universität Basel
Switzerland (CH)
Germany (DE)
University of Gothenburg / Göteborgs universitet
Sweden (SE)
University of Alabama at Birmingham (UAB)
United States (USA) (US)
Institute of Genetics and Molecular and Cellular Biology / Institut de génétique et de biologie moléculaire et cellulaire (IGBMC)
France (FR)
Netherlands Cancer Institute (NKI)
Netherlands (NL)
Universität Basel
Switzerland (CH)
How to cite
APA:
Song, J., Lokmic, Z., Laemmermann, T., Rolf, J., Wu, C., Zhang, X.,... Sorokin, L. (2013). Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proceedings of the National Academy of Sciences of the United States of America, 110(31). https://dx.doi.org/10.1073/pnas.1218131110
MLA:
Song, Jian, et al. "Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival." Proceedings of the National Academy of Sciences of the United States of America 110.31 (2013).
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