High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Edwards MH, Parsons C, Bruyere O, Dop FP, Chapurlat R, Roemer F, Guermazi A, Zaim S, Genant H, Reginster JY, Dennison EM, Cooper C
Zeitschrift: Journal of Rheumatology
Jahr der Veröffentlichung: 2016
Band: 43
Heftnummer: 3
Seitenbereich: 657-65
ISSN: 0315-162X


Abstract


Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW).A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) >= grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression.The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [? = -0.10 (95% CI -0.18, -0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW.The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Roemer, Frank Prof. Dr.
Radiologisches Institut


Einrichtungen weiterer Autorinnen und Autoren

Boston University
Servier
Synarc Inc
Université Claude Bernard Lyon 1 (UCB)
University of Liège (ULg) / Université de Liège
University of Southampton


Zitierweisen

APA:
Edwards, M.H., Parsons, C., Bruyere, O., Dop, F.P., Chapurlat, R., Roemer, F.,... Cooper, C. (2016). High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study. Journal of Rheumatology, 43(3), 657-65. https://dx.doi.org/10.3899/jrheum.150053

MLA:
Edwards, Mark H., et al. "High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study." Journal of Rheumatology 43.3 (2016): 657-65.

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Zuletzt aktualisiert 2018-10-10 um 02:30