Environmental factors in autoimmune diseases and their role in multiple sclerosis

Journal article

Publication Details

Author(s): Joerg S, Grohme DA, Erzler M, Binsfeld M, Haghikia A, Mueller DN, Linker R, Kleinewietfeld M
Journal: Cellular and Molecular Life Sciences
Publication year: 2016
Volume: 73
Journal issue: 24
Pages range: 4611-4622
ISSN: 1420-682X


An increase in autoimmune diseases poses a socioeconomic challenge worldwide. Predisposing genetic risk has been identified, yet environmental factors make up a significant part of the risk in disease initiation and propagation. Next to improved hygiene and a gross reduction of infections, changes in dietary habits are one of the most evident Western lifestyle factors potentially associated with the increase in autoimmune diseases. Growing evidence suggests that particularly a typical 'Western diet', rich in saturated fat and salt and related pathologies can have a profound impact on local and systemic immune responses under physiologic and autoimmune conditions such as in multiple sclerosis (MS). In this review, we discuss recent findings on environmental factors influencing autoimmunity with an emphasis on the impact of 'Western diet' on immune homeostasis and gut microbiota in MS.

FAU Authors / FAU Editors

Linker, Ralf PD Dr.
Stiftungsprofessur für Neuroimmunologie

External institutions with authors

Experimental and Clinical Research Center (ECRC)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Ruhr-Universität Bochum (RUB)
Technische Universität Dresden

How to cite

Joerg, S., Grohme, D.A., Erzler, M., Binsfeld, M., Haghikia, A., Mueller, D.N.,... Kleinewietfeld, M. (2016). Environmental factors in autoimmune diseases and their role in multiple sclerosis. Cellular and Molecular Life Sciences, 73(24), 4611-4622. https://dx.doi.org/10.1007/s00018-016-2311-1

Joerg, Stefanie, et al. "Environmental factors in autoimmune diseases and their role in multiple sclerosis." Cellular and Molecular Life Sciences 73.24 (2016): 4611-4622.


Last updated on 2018-10-10 at 02:30