Environmental factors in autoimmune diseases and their role in multiple sclerosis

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Joerg S, Grohme DA, Erzler M, Binsfeld M, Haghikia A, Mueller DN, Linker R, Kleinewietfeld M
Zeitschrift: Cellular and Molecular Life Sciences
Jahr der Veröffentlichung: 2016
Band: 73
Heftnummer: 24
Seitenbereich: 4611-4622
ISSN: 1420-682X


An increase in autoimmune diseases poses a socioeconomic challenge worldwide. Predisposing genetic risk has been identified, yet environmental factors make up a significant part of the risk in disease initiation and propagation. Next to improved hygiene and a gross reduction of infections, changes in dietary habits are one of the most evident Western lifestyle factors potentially associated with the increase in autoimmune diseases. Growing evidence suggests that particularly a typical 'Western diet', rich in saturated fat and salt and related pathologies can have a profound impact on local and systemic immune responses under physiologic and autoimmune conditions such as in multiple sclerosis (MS). In this review, we discuss recent findings on environmental factors influencing autoimmunity with an emphasis on the impact of 'Western diet' on immune homeostasis and gut microbiota in MS.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Linker, Ralf PD Dr.
Stiftungsprofessur für Neuroimmunologie

Einrichtungen weiterer Autorinnen und Autoren

Experimental and Clinical Research Center (ECRC)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Ruhr-Universität Bochum (RUB)
Technische Universität Dresden


Joerg, S., Grohme, D.A., Erzler, M., Binsfeld, M., Haghikia, A., Mueller, D.N.,... Kleinewietfeld, M. (2016). Environmental factors in autoimmune diseases and their role in multiple sclerosis. Cellular and Molecular Life Sciences, 73(24), 4611-4622. https://dx.doi.org/10.1007/s00018-016-2311-1

Joerg, Stefanie, et al. "Environmental factors in autoimmune diseases and their role in multiple sclerosis." Cellular and Molecular Life Sciences 73.24 (2016): 4611-4622.


Zuletzt aktualisiert 2018-10-10 um 02:30