Nitschke L (2005)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2005
Publisher: CURRENT BIOLOGY LTD
Book Volume: 17
Pages Range: 290-297
Journal Issue: 3
DOI: 10.1016/j.coi.2005.03.005
Inhibitory co-receptors downmodulate B-cell receptor (BCR) signalling by setting a signalling threshold that prevents overstimulation of B cells. Activation of these inhibitory co-receptors occurs by phosphorylation on their cytoplasmic inhibitory immunoreceptor tyrosine-based inhibition motifs (ITIMs), followed by recruitment of the tyrosine phosphatase SHP-1 or the lipid phosphatase SHIP, and depends on their association with the BCR. Recent evidence shows that B-cell signal inhibition is regulated by ligand binding of inhibitory receptors.
APA:
Nitschke, L. (2005). the role of CD22 and other inhibitory co-receptors in B-cell activation. Current Opinion in Immunology, 17(3), 290-297. https://doi.org/10.1016/j.coi.2005.03.005
MLA:
Nitschke, Lars. "the role of CD22 and other inhibitory co-receptors in B-cell activation." Current Opinion in Immunology 17.3 (2005): 290-297.
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