Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk

Journal article


Publication Details

Author(s): Boehm M, Schumacher H, Leong D, Mancia G, Unger T, Schmieder R, Custodis F, Diener HC, Laufs U, Lonn E, Sliwa K, Teo K, Fagard R, Redon J, Sleight P, Anderson C, O'Donnell M, Yusuf S
Journal: Hypertension
Publication year: 2015
Volume: 65
Journal issue: 3
Pages range: 651-61
ISSN: 0194-911X
eISSN: 1524-4563


Abstract

Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/mean×100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination <=24 points), important cognitive decline (drop of >=5 points), and cognitive deterioration (drop of >1 point per year or decline to <24 points) were assessed. SBP and HR were measured over 10.7±2.2 (mean±SD) visits. Mean SBP, mean HR, and SBP-CV were associated with cognitive decline, dysfunction, and deterioration (all P<0.01, unadjusted). After adjustment, only SBP-CV (P=0.0030) and mean HR (P=0.0008) remained predictors for cognitive dysfunction (odds ratios [95% confidence intervals], 1.32 [1.10-1.58] for 5th versus 1st quintile of SBP-CV and 1.40 [1.18-1.66] for 5th versus 1st quintile of mean HR). Similar effects were observed for cognitive decline and deterioration. SBP-CV and mean HR showed additive effects. In conclusion, SBP-CV and mean HR are independent predictors of cognitive decline and cognitive dysfunction in patients at high CV risk.http://www.clinicaltrials.gov. Unique identifier: NCT 00153101.


FAU Authors / FAU Editors

Schmieder, Roland Prof. Dr.
Professur für Innere Medizin (Nephrologie)


External institutions with authors

Boehringer Ingelheim Pharma GmbH & Co. KG
John Radcliffe Hospital
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Maastricht University
McMaster University
National University of Ireland (NUI), Galway
Universitätsklinikum des Saarlandes
Universitätsklinikum Essen
University of Cape Town (UCT)
University of Milano-Bicocca / Università degli Studi di Milano-Bicocca, UNIMIB
University of Sydney
University of València / Universitat de València


How to cite

APA:
Boehm, M., Schumacher, H., Leong, D., Mancia, G., Unger, T., Schmieder, R.,... Yusuf, S. (2015). Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk. Hypertension, 65(3), 651-61. https://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04568

MLA:
Boehm, Michael, et al. "Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk." Hypertension 65.3 (2015): 651-61.

BibTeX: 

Last updated on 2018-10-10 at 02:28