CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

Wiede F, Fromm PD, Comerford I, Kara E, Bannan J, Schuh W, Ranasinghe C, Tarlinton D, Winkler T, Mccoll SR, Koerner H (2013)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Immunology and Cell Biology Nature Publishing Group: Open Access Hybrid Model Option A

Publisher: NATURE PUBLISHING GROUP

Book Volume: 91

Pages Range: 335-339

Journal Issue: 5

DOI: 10.1038/icb.2013.14

Abstract

The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naive B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6(-/-) mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6(-/-) B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.

Authors with CRIS profile

Wolfgang Schuh Department of Molecular Immunology Thomas Winkler Professur für Genetik

Involved external institutions

University of Adelaide AU Australia (AU) University of Tasmania (UTAS) AU Australia (AU) Australian National University (ANU) AU Australia (AU) Walter and Eliza Hall Institute of Medical Research (WEHI) AU Australia (AU) James Cook University AU Australia (AU)

How to cite

APA:

Wiede, F., Fromm, P.D., Comerford, I., Kara, E., Bannan, J., Schuh, W.,... Koerner, H. (2013). CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse. Immunology and Cell Biology, 91(5), 335-339. https://dx.doi.org/10.1038/icb.2013.14

MLA:

Wiede, Florian, et al. "CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse." Immunology and Cell Biology 91.5 (2013): 335-339.

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