Relationship between the area of isopters and Vigabatrin dosage during two years of observation

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Nowomiejska K, Jedrych M, Brzozowska A, Rejdak K, Zarnowski T, Koss MJ, Ksiazek K, Ksiazek P, Maciejewski R, Jünemann A, Schiefer U, Rejdak R
Zeitschrift: Bmc Ophthalmology
Jahr der Veröffentlichung: 2014
Band: 14
Seitenbereich: 56
ISSN: 1471-2415


The aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patients with pretreatment baseline examination during 2-years of the follow-up.29 epilepsy patients were included into the study, but 15 individuals were excluded due to cognitive impairment, intracranial pathologies or eye diseases. Finally, 14 patients were examined with SKP before VGB treatment and after 6, 12, 18, and 24 months. Reaction time (RT)-corrected areas of three isopters (III4e, I4e and I2e) were measured for each of five examinations and compared intra-individually during 2-years period. Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as a control.There was a significant decrease of I2e, I4e and III4e isopters' area during the follow-up of two years. Correlation was found between the I2e isopter's area and both cumulative dose and mean daily dose of VGB. With increasing RT, there was decreasing of all isopters' area in patients receiving VGB. In epilepsy patients who were not receiving VGB, there were no significance differences in isopters' area during follow-up.There was attenuation of area of III4e, I4e and I2e isopters obtained with SKP during a period of 2 years. RT, the cumulative dose and the mean daily dose of VGB influenced isopters' area obtained with SKP.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Jünemann, Anselm Prof. Dr.
Medizinische Fakultät

Einrichtungen weiterer Autorinnen und Autoren

Eberhard Karls Universität Tübingen
Medical University of Lublin / Uniwersytet Medyczny w Lublinie
Ruprecht-Karls-Universität Heidelberg


Nowomiejska, K., Jedrych, M., Brzozowska, A., Rejdak, K., Zarnowski, T., Koss, M.J.,... Rejdak, R. (2014). Relationship between the area of isopters and Vigabatrin dosage during two years of observation. Bmc Ophthalmology, 14, 56.

Nowomiejska, Katarzyna, et al. "Relationship between the area of isopters and Vigabatrin dosage during two years of observation." Bmc Ophthalmology 14 (2014): 56.


Zuletzt aktualisiert 2019-23-07 um 07:54