Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Matuszak J, Baumgartner J, Zaloga J, Juenet M, Da Silva AE, Franke D, Almer G, Texier I, Faivre D, Metselaar JM, Navarro FP, Chauvierre C, Prassl R, Dezsi L, Urbanics R, Alexiou C, Mangge H, Szebeni J, Letourneur D, Cicha I
Zeitschrift: Nanomedicine
Jahr der Veröffentlichung: 2016
Band: 11
Heftnummer: 6
Seitenbereich: 597-616
ISSN: 1743-5889


Abstract

We report the physicochemical analysis of nanosystems intended for cardiovascular applications and their toxicological characterization in static and dynamic cell culture conditions.Size, polydispersity and ?-potential were determined in 10 nanoparticle systems including liposomes, lipid nanoparticles, polymeric and iron oxide nanoparticles. Nanoparticle effects on primary human endothelial cell viability were monitored using real-time cell analysis and live-cell microscopy in static conditions, and in a flow model of arterial bifurcations.The majority of tested nanosystems were well tolerated by endothelial cells up to the concentration of 100 ?g/ml in static, and up to 400 ?g/ml in dynamic conditions. Pilot experiments in a pig model showed that intravenous administration of liposomal nanoparticles did not evoke the hypersensitivity reaction. These findings are of importance for future clinical use of nanosystems intended for intravascular applications.


FAU-Autoren / FAU-Herausgeber

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin
Matuszak, Jasmin
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Zaloga, Jan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie


Autor(en) der externen Einrichtung(en)
Max-Planck-Institut für Kolloid- und Grenzflächenforschung / Max Planck Institute of Colloids and Interfaces
nanoPET Pharma GmbH
Semmelweis University
SeroScience Ltd
Université Paris XIII / Université Paris Nord (UP13)
University of Grenoble Alpes (UGA) / Université de Grenoble
University of Twente


Zitierweisen

APA:
Matuszak, J., Baumgartner, J., Zaloga, J., Juenet, M., Da Silva, A.E., Franke, D.,... Cicha, I. (2016). Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing. Nanomedicine, 11(6), 597-616. https://dx.doi.org/10.2217/nnm.15.216

MLA:
Matuszak, Jasmin, et al. "Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing." Nanomedicine 11.6 (2016): 597-616.

BibTeX: 

Zuletzt aktualisiert 2018-10-10 um 02:27