Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs

Journal article
(Review article)


Publication Details

Author(s): Pischetsrieder M, Gensberger-Reigl S, Atzenbeck L, Weigel I
Journal: Drug Discovery Today
Publisher: Elsevier
Publication year: 2016
Volume: 21
Journal issue: 10
Pages range: 1620-1631
ISSN: 1359-6446
Language: English


Abstract


Carbohydrate degradation products are formed during heat sterilization in

drugs containing (poly-)glucose as osmotic agents. Given this situation,

peritoneal dialysis fluids (PDFs) and infusion fluids are of particular

clinical relevance, because these drugs deliver process contaminants either

over a longer period or directly into the circulation of patients who are

critically ill. For the development of suitable mitigation strategies, it is

important to understand the reaction mechanisms of carbohydrate

degradation during sterilization and how the resulting products interact

with physiological targets at the molecular level. Furthermore, reliable,

comprehensive, and highly sensitive quantification methods are required

for product control and toxicological evaluation.



FAU Authors / FAU Editors

Atzenbeck, Lisa
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Gensberger-Reigl, Sabrina Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)
Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)


Additional Organisation
Emil-Fischer-Zentrum (Emil Fischer Center)


How to cite

APA:
Pischetsrieder, M., Gensberger-Reigl, S., Atzenbeck, L., & Weigel, I. (2016). Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs. Drug Discovery Today, 21(10), 1620-1631. https://dx.doi.org/10.1016/j.drudis.2016.06.011

MLA:
Pischetsrieder, Monika, et al. "Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs." Drug Discovery Today 21.10 (2016): 1620-1631.

BibTeX: 

Last updated on 2018-19-04 at 03:29