The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months

Journal article


Publication Details

Author(s): Stockmann P, Burger M, von Wilmowsky C, Ebker T, Lutz R, Bauersachs A, Nkenke E, Neukam FW, Wehrhan F
Journal: Clinical Oral Investigations
Publisher: Springer Verlag (Germany)
Publication year: 2014
Volume: 18
Journal issue: 4
Pages range: 1299-304
ISSN: 1432-6981


Abstract


The present case series evaluates the success rate of osteotomy and primary wound closure in patients with bisphosphonate-associated osteonecrosis of the jaw (BRONJ).Eighty patients suffering from BRONJ were included in the study. All patients received intravenous bisphosphonate therapy and underwent osteotomy and primary wound closure according to a standardised protocol. After discharge, the patients were reviewed on a regular basis over an average time period of 20 months.During follow-up in 11 patients, a recurrence of BRONJ occurred in the former operation field. Seventeen patients died due to their underlying disease. The success rate of osteotomy and primary wound closure in the treatment of BRONJ was calculated at 84.2 % 20 months after surgery. The results showed non-significant difference concerning the outcome of surgery in the different clinical stages of BRONJ.In accordance with previous studies, stage-independent osteotomy and primary wound closure combined with antibiotics shall be deemed a viable treatment option in patients suffering from BRONJ.With a high success rate, osteotomy in combination with primary wound closure seems to be a viable alternative to more conservative protocols in the treatment of BRONJ.



FAU Authors / FAU Editors

Lutz, Rainer PD Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik
Neukam, Friedrich Wilhelm Prof. Dr. Dr.
Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie
Stockmann, Philipp PD Dr. Dr.
Medizinische Fakultät
von Wilmowsky, Cornelius PD Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik
Wehrhan, Falk PD Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik


How to cite

APA:
Stockmann, P., Burger, M., von Wilmowsky, C., Ebker, T., Lutz, R., Bauersachs, A.,... Wehrhan, F. (2014). The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months. Clinical Oral Investigations, 18(4), 1299-304. https://dx.doi.org/10.1007/s00784-013-1092-2

MLA:
Stockmann, Philipp, et al. "The outcome after surgical therapy of bisphosphonate-associated osteonecrosis of the jaw--results of a clinical case series with an average follow-up of 20 months." Clinical Oral Investigations 18.4 (2014): 1299-304.

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Last updated on 2019-25-02 at 07:08