Regioselective Radical Arylation of 3-Hydroxypyridines

Fürst M, Bock L, Heinrich M (2016)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2016

Journal

Journal of Organic Chemistry American Chemical Society

Publisher: American Chemical Society

Book Volume: 81

Pages Range: 5752-5758

Journal Issue: 13

DOI: 10.1021/acs.joc.6b00894

Abstract

The titanium(III)-mediated radical arylation of 3-hydroxypyridines was found to proceed with high regioselectivity for the 2-position. Using aryldiazonium chlorides, which were prepared from the corresponding anilines, as aryl radical sources, a range of 3-hydroxy-2-phenylpyridines were obtained in moderate to good yields under simple reaction conditions. Reactions of ortho-carboxylic ester substituted phenyldiazonium salts directly provided tricyclic benzopyranopyridinones.

Authors with CRIS profile

Michael Fürst Professur für Pharmazeutische Chemie Leonard Bock Professur für Pharmazeutische Chemie Markus Heinrich Professur für Pharmazeutische Chemie

How to cite

APA:

Fürst, M., Bock, L., & Heinrich, M. (2016). Regioselective Radical Arylation of 3-Hydroxypyridines. Journal of Organic Chemistry, 81(13), 5752-5758. https://dx.doi.org/10.1021/acs.joc.6b00894

MLA:

Fürst, Michael, Leonard Bock, and Markus Heinrich. "Regioselective Radical Arylation of 3-Hydroxypyridines." Journal of Organic Chemistry 81.13 (2016): 5752-5758.

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