DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

Lehmann C, Baranska A, Heidkamp GF, Heger L, Neubert K, Luehr JJ, Hoffmann A, Reimer K, Brückner C, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D (2017)


Publication Status: Published

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 214

Pages Range: 1509-1528

Journal Issue: 5

DOI: 10.1084/jem.20160951

Abstract

Dendritic cells (DCs) are efficient antigen-presenting cells equipped with various cell surface receptors for the direct or indirect recognition of pathogenic microorganisms. Interestingly, not much is known about the specific expression pattern and function of the individual activating and inhibitory Fcγ receptors (FcγRs) on splenic DC subsets in vivo and how they contribute to the initiation of T cell responses. By targeting antigens to select activating and the inhibitory FcγR in vivo, we show that antigen uptake under steady-state conditions results in a short-term expansion of antigen-specific T cells, whereas under inflammatory conditions especially, the activating FcγRIV is able to induce superior CD4(+) and CD8(+) T cell responses. Of note, this effect was independent of FcγR intrinsic activating signaling pathways. Moreover, despite the expression of FcγRIV on both conventional splenic DC subsets, the induction of CD8(+) T cell responses was largely dependent on CD11c(+)CD8(+) DCs, whereas CD11c(+)CD8(-) DCs were critical for priming CD4(+) T cell responses.

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APA:

Lehmann, C., Baranska, A., Heidkamp, G.F., Heger, L., Neubert, K., Luehr, J.J.,... Dudziak, D. (2017). DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo. Journal of Experimental Medicine, 214(5), 1509-1528. https://dx.doi.org/10.1084/jem.20160951

MLA:

Lehmann, Christian, et al. "DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo." Journal of Experimental Medicine 214.5 (2017): 1509-1528.

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