Bach C, Slany R (2009)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2009
Book Volume: 5
Pages Range: 1271-1281
Journal Issue: 8
DOI: 10.2217/fon.09.96
Genomic rearrangements of the locus 11q23 are frequently observed in aggressive acute leukemias with poor prognosis. These chromosomal aberrations fuse the mixed-lineage leukemia (MLL) gene to one of more than 50 partners. The resulting mixed-lineage leukemia fusions often code for chimeric transcriptional activators, which are able to transform normal hematopoietic cells through the deregulation of leukemogenic target genes. This review provides a concise overview about the known functions encoded in MLL and the respective fusion partners. Additionally, the roles of some target genes, as well as co-factors of mixedlineage leukemia fusion proteins, are described with an emphasis on recent advances potentially uncovering novel therapeutic targets. © 2009 Future Medicine Ltd.
APA:
Bach, C., & Slany, R. (2009). Molecular pathology of mixed-lineage leukemia. Future Oncology, 5(8), 1271-1281. https://doi.org/10.2217/fon.09.96
MLA:
Bach, Christian, and Robert Slany. "Molecular pathology of mixed-lineage leukemia." Future Oncology 5.8 (2009): 1271-1281.
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