Influence of 3D QCT scan protocol on the QCT-based finite element models of human vertebral cancellous bone

Lu Y, Engelke K, Pueschel K, Morlock MM, Huber G (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Medical Engineering & Physics Elsevier

Publisher: Elsevier

Book Volume: 36

Pages Range: 1069-73

Journal Issue: 8

DOI: 10.1016/j.medengphy.2014.05.001

Abstract

Quantitative computed tomography (QCT)-based finite element (FE) models provide a better prediction of vertebral strength than dual-energy X-ray absorptiometry. However, FE models are often created from datasets acquired at different CT scan protocols and it is unclear whether this influences the FE results. The aim of this paper was to investigate whether there was an effect of the CT scan protocol on the FE models. 12 human thoracolumbar vertebrae were scanned on top of a calcium hydroxyapatite calibration phantom using a standard QCT scan protocol - 120kV, 100mAs (PA); and a low dose protocol - 90kV, 150mAs (PB). FE cancellous models with cuboid volume of interest and inhomogeneous nonlinear bone properties were created. Axial compression was simulated. The apparent BMD, modulus and yield strength showed significant differences between the two scan protocols. The apparent BMD, the modulus and yield strength between the two groups were highly linearly correlated. This paper indicated that the FE models created from image datasets acquired at different X-ray tube voltage settings would give significantly different results and this effect could be possibly corrected using a linear correction approach.

Authors with CRIS profile

Klaus Engelke Lehrstuhl für Medizinische Physik und Mikrogewebetechnik

Involved external institutions

Technische Universität Hamburg-Harburg (TUHH) DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE)

How to cite

APA:

Lu, Y., Engelke, K., Pueschel, K., Morlock, M.M., & Huber, G. (2014). Influence of 3D QCT scan protocol on the QCT-based finite element models of human vertebral cancellous bone. Medical Engineering & Physics, 36(8), 1069-73. https://dx.doi.org/10.1016/j.medengphy.2014.05.001

MLA:

Lu, Yongtao, et al. "Influence of 3D QCT scan protocol on the QCT-based finite element models of human vertebral cancellous bone." Medical Engineering & Physics 36.8 (2014): 1069-73.

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