Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Schmiele M, Busch S, Morhenn H, Schindler T, Schmutzler T, Schweins R, Lindner P, Boesecke P, Westermann M, Steiniger F, Funari SS, Unruh T
Zeitschrift: Journal of Physical Chemistry B
Verlag: American Chemical Society
Jahr der Veröffentlichung: 2016
Band: 120
Heftnummer: 24
Seitenbereich: 5513-5526
ISSN: 1520-6106
eISSN: 1520-5207


Abstract


Using photon correlation spectroscopy, transmission electron microscopy, microcalorimetry, wide-angle X-ray scattering (WAXS), and small-angle X-ray and neutron scattering (SAXS, SANS), the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)-stabilized colloidal tetracosane suspensions was studied from the molecular level to the microscopic scale as a function of the temperature. The platelike nanocrystals exhibit for tetracosane an unusual orthorhombic low-temperature crystal structure. The corresponding WAXS pattern can be reproduced with a predicted orthorhombic unit cell (space group Pca2), which usually occurs only for much longer even-numbered n-alkanes. Special emphasis was placed on the structure of the DMPC stabilizer layer covering the nanocrystals. Their structure was investigated by SAXS and SANS, using suspensions with different neutron scattering contrasts. As for the emulsions in Part I, the crystallized nanoparticles are covered by a DMPC monolayer. Their significant smaller thickness of 10.5 å (for the emulsions in Part I: 16 å) could be related to a more tilted orientation of the DMPC molecules to cover the expanded surface of the crystallized nanoparticles.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Schindler, Torben
Schmutzler, Tilo
Professur für Nanomaterialcharakterisierung (Streumethoden)
Professur für Nanomaterialcharakterisierung (Streumethoden)
Schmiele, Martin
Unruh, Tobias Prof. Dr.
Professur für Nanomaterialcharakterisierung (Streumethoden)
Professur für Nanomaterialcharakterisierung (Streumethoden)


Zusätzliche Organisationseinheit(en)
Graduiertenkolleg 1896/2 In situ Mikroskopie mit Elektronen, Röntgenstrahlen und Rastersonden
Exzellenz-Cluster Engineering of Advanced Materials
Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)


Einrichtungen weiterer Autorinnen und Autoren

Deutsches Elektronen-Synchrotron DESY
European Synchrotron Radiation Facility (ESRF)
Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG)
Institute Laue-Langevin (ILL)
Technische Universität München (TUM)
Universitätsklinikum Jena


Forschungsbereiche

A2 Nanoanalysis and Microscopy
Exzellenz-Cluster Engineering of Advanced Materials


Zitierweisen

APA:
Schmiele, M., Busch, S., Morhenn, H., Schindler, T., Schmutzler, T., Schweins, R.,... Unruh, T. (2016). Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions. Journal of Physical Chemistry B, 120(24), 5513-5526. https://dx.doi.org/10.1021/acs.jpcb.6b02520

MLA:
Schmiele, Martin, et al. "Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions." Journal of Physical Chemistry B 120.24 (2016): 5513-5526.

BibTeX: 

Zuletzt aktualisiert 2019-04-06 um 15:23