Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes

Hoffmann SA, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Development Company of Biologists

Publisher: Company of Biologists

Book Volume: 141

Pages Range: 39-50

Journal Issue: 1

DOI: 10.1242/dev.098418

Abstract

Neural precursor cells of the ventricular zone give rise to all neurons and glia of the central nervous system and rely for maintenance of their precursor characteristics on the closely related SoxB1 transcription factors Sox1, Sox2 and Sox3. We show in mouse spinal cord that, whereas SoxB1 proteins are usually downregulated upon neuronal specification, they continue to be expressed in glial precursors. In the oligodendrocyte lineage, Sox2 and Sox3 remain present into the early phases of terminal differentiation. Surprisingly, their deletion does not alter precursor characteristics but interferes with proper differentiation. Although a direct influence on myelin gene expression may be part of their function, we provide evidence for another mode of action. SoxB1 proteins promote oligodendrocyte differentiation in part by negatively controlling miR145 and thereby preventing this microRNA from inhibiting several pro-differentiation factors. This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions.

Authors with CRIS profile

Stephanie Annie Hoffmann Lehrstuhl für Biochemie und Pathobiochemie Melanie Küspert Lehrstuhl für Biochemie und Pathobiochemie Michael Wegner Lehrstuhl für Biochemie und Pathobiochemie Simone Reiprich Lehrstuhl für Biochemie und Pathobiochemie

Involved external institutions

Cincinnati Children's Hospital Medical Center US United States (USA) (US) National Institute for Medical Research GB United Kingdom (GB)

How to cite

APA:

Hoffmann, S.A., Hos, D., Küspert, M., Lang, R.A., Lovell-Badge, R., Wegner, M., & Reiprich, S. (2014). Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development, 141(1), 39-50. https://dx.doi.org/10.1242/dev.098418

MLA:

Hoffmann, Stephanie Annie, et al. "Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes." Development 141.1 (2014): 39-50.

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