Structural changes and binding characteristics of the tetracycline-repressor binding site on induction

Journal article


Publication Details

Author(s): Lanig H, Othersen O, Seidel U, Beierlein F, Exner T, Clark T
Journal: Journal of Medicinal Chemistry
Publisher: American Chemical Society
Publication year: 2006
Volume: 49
Journal issue: 12
Pages range: 3444-3447
ISSN: 0022-2623


Abstract


The binding motif ( pharmacophore) for induction and the changes in the structure of the binding site that accompany induction have been determined from molecular-dynamics simulations on the tetracycline-repressor signal-transduction protein. The changes and the induction mechanism are discussed and compared with conclusions drawn from earlier X-ray structures. The differences in inducer strength of tetracycline and 5a, 6-anhydrotetracycline are discussed with respect to their interaction in the MD simulations.



FAU Authors / FAU Editors

Beierlein, Frank Dr.
Computer-Chemie-Centrum
Clark, Timothy apl. Prof. Dr.
Computer-Chemie-Centrum
Lanig, Harald PD Dr.
Exzellenz-Cluster Engineering of Advanced Materials


How to cite

APA:
Lanig, H., Othersen, O., Seidel, U., Beierlein, F., Exner, T., & Clark, T. (2006). Structural changes and binding characteristics of the tetracycline-repressor binding site on induction. Journal of Medicinal Chemistry, 49(12), 3444-3447. https://dx.doi.org/10.1021/jm060289g

MLA:
Lanig, Harald, et al. "Structural changes and binding characteristics of the tetracycline-repressor binding site on induction." Journal of Medicinal Chemistry 49.12 (2006): 3444-3447.

BibTeX: 

Last updated on 2018-19-04 at 03:25