Formation of Guanosine Adducts from L-Ascorbic Acid under Oxidative Conditions

Journal article


Publication Details

Author(s): Larisch B, Pischetsrieder M, Severin T
Journal: Bioorganic & Medicinal Chemistry Letters
Publisher: Elsevier
Publication year: 1997
Volume: 7
Pages range: 2681-2686
ISSN: 0960-894X


Abstract


L-Ascorbic acid (AA) was incubated with guanosine under physiological conditions and the reaction was monitored by HPLC-DAD. Four reaction products were isolated and identified as two pairs of diastereomers of N2-(1-Carboxyethyl)-guanosine and N2-(1-Carboxy-3-hydroxypropyl)-guanosine respectively. They were formed from AA in the presence of oxygen as well as from its degradation products L-dehydroascorbic acid and L-xylosone.



How to cite

APA:
Larisch, B., Pischetsrieder, M., & Severin, T. (1997). Formation of Guanosine Adducts from L-Ascorbic Acid under Oxidative Conditions. Bioorganic & Medicinal Chemistry Letters, 7, 2681-2686. https://dx.doi.org/10.1016/S0960-894X(97)10056-7

MLA:
Larisch, Bernd, Monika Pischetsrieder, and Theodor Severin. "Formation of Guanosine Adducts from L-Ascorbic Acid under Oxidative Conditions." Bioorganic & Medicinal Chemistry Letters 7 (1997): 2681-2686.

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Last updated on 2018-19-04 at 02:37