Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites
Sarter K, Kulagin M, Schett G, Harris NL, Zaiss MM (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Pages Range: 1-7
DOI: 10.1080/08916934.2016.1261837
Abstract
Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory-secretory (ES) products from Hp directly suppress osteoclast differentiation in vitro. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.
Authors with CRIS profile
Involved external institutions
École Polytechnique Fédérale de Lausanne (EPFL)
Switzerland (CH)
Julius-Maximilians-Universität Würzburg
Germany (DE)
Switzerland (CH)
Julius-Maximilians-Universität Würzburg
Germany (DE)
How to cite
APA:
Sarter, K., Kulagin, M., Schett, G., Harris, N.L., & Zaiss, M.M. (2017). Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites. Autoimmunity, 1-7. https://dx.doi.org/10.1080/08916934.2016.1261837
MLA:
Sarter, Kerstin, et al. "Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites." Autoimmunity (2017): 1-7.
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