Definition of K(trans) and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study

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Details zur Publikation

Autorinnen und Autoren: Engelhorn T, Schwarz M, Heß A, Budinsky L, Pitann P, Eyüpoglu IY, Dörfler A
Zeitschrift: Clinical Neuroradiology
Verlag: Springer Verlag (Germany)
Jahr der Veröffentlichung: 2014
Band: 24
Heftnummer: 4
Seitenbereich: 337-45
ISSN: 1869-1439


Abstract

To define K(trans) and fractional anisotropy (FA) thresholds in correlation to histology for improved magnetic resonance imaging (MRI) tumor assessment in an animal model of brain glioma.Twelve rats underwent 4.7 T MRI at day 10 after tumor implantation. Anatomical scans (T2, T1 at 8 min after double dose contrast application) as well as dynamic contrast-enhanced (DCE) imaging with calculation of K(trans) and diffusion tensor imaging (DTI) with calculation of FA were performed. T2- and T1-derived tumor volumes were calculated and thresholds for K(trans) and FA were defined for best MRI tumor assessment correlated to histology.Tumor volumes were 159 ± 14 mm(3) (histology), 126 ± 26 mm(3) (T1 with contrast, r = 0.76), and 153 ± 12 mm(3) (T2, r = 0.84), respectively. K(trans)- and FA-derived tumor volumes were 160 ± 16 mm(3) (for K(trans) ³ 0.04 min(-1), r = 0.94), and 159 ± 14 mm(3) (for FA £ 0.14, r = 0.96), respectively.DCE-MRI and DTI with calculation of K(trans) and FA maps allow very precise brain glioma assessment comparable to histology if established thresholds for the given tumor model are used.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Budinsky, Lubos Dr.
Lehrstuhl für Pharmakologie und Toxikologie
Dörfler, Arnd Prof. Dr.
Neuroradiologische Abteilung im Radiologischen Institut
Eyüpoglu, Ilker Yasin Prof. Dr.
Neurochirurgische Klinik
Heß, Andreas Prof. Dr.
Lehrstuhl für Pharmakologie und Toxikologie
Pitann, Patrick
Medizinische Fakultät
Schwarz, Martin
Professur für Experimentelle Augenheilkunde


Zitierweisen

APA:
Engelhorn, T., Schwarz, M., Heß, A., Budinsky, L., Pitann, P., Eyüpoglu, I.Y., & Dörfler, A. (2014). Definition of K(trans) and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study. Clinical Neuroradiology, 24(4), 337-45. https://dx.doi.org/10.1007/s00062-013-0257-3

MLA:
Engelhorn, Tobias, et al. "Definition of K(trans) and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study." Clinical Neuroradiology 24.4 (2014): 337-45.

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Zuletzt aktualisiert 2018-09-10 um 07:26