DNA methylation of the LEP gene is associated with craving during alcohol withdrawal

Hillemacher T, Weinland C, Lenz B, Kraus T, Heberlein A, Glahn A, Muschler MAN, Bleich S, Kornhuber J, Frieling H (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Psychoneuroendocrinology Elsevier

Book Volume: 51

Pages Range: 371-7

DOI: 10.1016/j.psyneuen.2014.10.014

Abstract

Different studies have described evidence for an association between leptin serum levels and craving in alcohol dependent patients. As leptin expression is regulated by DNA methylation we investigated changes of DNA methylation of the LEP gene promoter region in alcohol dependent patients undergoing withdrawal. Results show that low methylation status is associated with increasing serum leptin levels and elevation of craving for alcohol in the referring patients group. These findings point towards a pathophysiological relevance of changes in DNA methylation of the LEP gene promoter region in alcohol dependence.

Authors with CRIS profile

Bernd Lenz Medizinische Fakultät Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Hillemacher, T., Weinland, C., Lenz, B., Kraus, T., Heberlein, A., Glahn, A.,... Frieling, H. (2015). DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. Psychoneuroendocrinology, 51, 371-7. https://doi.org/10.1016/j.psyneuen.2014.10.014

MLA:

Hillemacher, Thomas, et al. "DNA methylation of the LEP gene is associated with craving during alcohol withdrawal." Psychoneuroendocrinology 51 (2015): 371-7.

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