Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.

Journal article


Publication Details

Author(s): Müller J, Lunz B, Schwab I, Acs A, Nimmerjahn F, Daniel C, Nitschke L
Journal: Journal of immunology (Baltimore, Md. : 1950)
Publication year: 2015
Volume: 195
Journal issue: 1
Pages range: 51-60
ISSN: 1550-6606


Abstract


Siglec-G, a member of the sialic acid-binding Ig-like lectin (Siglec) family, is expressed on B cell and dendritic cell surfaces. It acts as an inhibitory coreceptor and modulates B cell activation, especially on B1 cells, as Siglec-G-deficient mice show mainly a B1 cell-restricted phenotype resulting in increased B1 cell numbers. Although higher B1 cell numbers are discussed to be associated with autoimmunity, loss of Siglec-G does not result in autoimmune disease in BALB/c mice. However, there is evidence from Siglec-G × CD22 double-deficient mice and Siglec-G(-/-) mice on an autoimmune-prone MRL/lpr background that Siglec-G is important to maintain tolerance in B cells. In this study, we analyzed the role of Siglec-G in induction and maintenance of B cell tolerance on C57BL/6 background and in the FcγRIIb-deficient background. We find that aging Siglec-G-deficient and Siglec-G × FcγRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis. Aging Siglec-G-deficient mice have elevated numbers of plasma cells and germinal center B cells, as well as a higher number of activated CD4 T cells, which likely all contribute to autoantibody production. Additional loss of the inhibitory receptor FcγRIIb in Siglec-G(-/-) mice does not result in exacerbation of disease. These results indicate that Siglec-G is important to maintain tolerance in B cells and prevent autoimmunity.



FAU Authors / FAU Editors

Acs, Andreas
Professur für Genetik
Daniel, Christoph Prof. Dr.
Nephropathologische Abteilung im Pathologischen Institut
Müller, Jennifer
Professur für Genetik
Nimmerjahn, Falk Prof. Dr.
Lehrstuhl für Genetik
Nitschke, Lars Prof. Dr.
Professur für Genetik


How to cite

APA:
Müller, J., Lunz, B., Schwab, I., Acs, A., Nimmerjahn, F., Daniel, C., & Nitschke, L. (2015). Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice. Journal of immunology (Baltimore, Md. : 1950), 195(1), 51-60. https://dx.doi.org/10.4049/jimmunol.1403139

MLA:
Müller, Jennifer, et al. "Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice." Journal of immunology (Baltimore, Md. : 1950) 195.1 (2015): 51-60.

BibTeX: 

Last updated on 2018-08-08 at 06:42