Müller J, Lunz B, Schwab I, Acs A, Nimmerjahn F, Daniel C, Nitschke L (2015)
Publication Status: Published
Publication Type: Journal article
Publication year: 2015
Book Volume: 195
Pages Range: 51-60
Journal Issue: 1
Siglec-G, a member of the sialic acid-binding Ig-like lectin (Siglec) family, is expressed on B cell and dendritic cell surfaces. It acts as an inhibitory coreceptor and modulates B cell activation, especially on B1 cells, as Siglec-G-deficient mice show mainly a B1 cell-restricted phenotype resulting in increased B1 cell numbers. Although higher B1 cell numbers are discussed to be associated with autoimmunity, loss of Siglec-G does not result in autoimmune disease in BALB/c mice. However, there is evidence from Siglec-G × CD22 double-deficient mice and Siglec-G(-/-) mice on an autoimmune-prone MRL/lpr background that Siglec-G is important to maintain tolerance in B cells. In this study, we analyzed the role of Siglec-G in induction and maintenance of B cell tolerance on C57BL/6 background and in the FcγRIIb-deficient background. We find that aging Siglec-G-deficient and Siglec-G × FcγRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis. Aging Siglec-G-deficient mice have elevated numbers of plasma cells and germinal center B cells, as well as a higher number of activated CD4 T cells, which likely all contribute to autoantibody production. Additional loss of the inhibitory receptor FcγRIIb in Siglec-G(-/-) mice does not result in exacerbation of disease. These results indicate that Siglec-G is important to maintain tolerance in B cells and prevent autoimmunity.
APA:
Müller, J., Lunz, B., Schwab, I., Acs, A., Nimmerjahn, F., Daniel, C., & Nitschke, L. (2015). Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice. Journal of Immunology, 195(1), 51-60. https://dx.doi.org/10.4049/jimmunol.1403139
MLA:
Müller, Jennifer, et al. "Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice." Journal of Immunology 195.1 (2015): 51-60.
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