ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting

Journal article


Publication Details

Author(s): Marx A, Stroebel P, Badve SS, Chalabreysse L, Chan JKC, Chen G, De Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD
Journal: Journal of Thoracic Oncology
Publication year: 2014
Volume: 9
Journal issue: 5
Pages range: 596-611
ISSN: 1556-0864
eISSN: 1556-1380


Abstract


The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.To overcome this problem, hematoxylin-eosin-stained and immunohistochemically processed sections of prototypic, "borderland," and "combined" thymomas and TC (n = 72) were studied by 18 pathologists at an international consensus slide workshop supported by the International Thymic Malignancy Interest Group.Consensus was achieved on refined criteria for decision making at the A/AB borderland, the distinction between B1, B2, and B3 thymomas and the separation of B3 thymomas from TCs. "Atypical type A thymoma" is tentatively proposed as a new type A thymoma variant. New reporting strategies for tumors with more than one histological pattern are proposed.These guidelines can set the stage for reproducibility studies and the design of a clinically meaningful grading system for thymic epithelial tumors.



External institutions with authors

Catholic University of the Sacred Heart / Università Cattolica del Sacro Cuore
CDI Centro Diagnostico Italiano S.p.A.
Christie NHS Foundation Trust
Fondazione IRCCS: Istituto Nazionale dei Tumori
Hokkaido University (Hokudai) / 北海道大学
Hospices Civils de Lyon (CHU)
Indiana University
Lausanne University Hospital / Centre hospitalier universitaire vaudois (CHUV)
Memorial Sloan Kettering Cancer Center
Queen Elizabeth Hospital / 伊利沙伯醫院
Royal Brompton Hospital
Ruprecht-Karls-Universität Heidelberg
Saiseikai Central Hospital
Shanghai Pulmonary Hospital
University of Paris 5 - René Descartes / Université Paris V René Descartes
University of Turin / Università degli Studi di Torino (UNITO)


How to cite

APA:
Marx, A., Stroebel, P., Badve, S.S., Chalabreysse, L., Chan, J.K.C., Chen, G.,... Travis, W.D. (2014). ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting. Journal of Thoracic Oncology, 9(5), 596-611. https://dx.doi.org/10.1097/JTO.0000000000000154

MLA:
Marx, Alexander, et al. "ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting." Journal of Thoracic Oncology 9.5 (2014): 596-611.

BibTeX: 

Last updated on 2018-09-10 at 07:25