Genetic variants of methionine metabolism and DNA methylation

Bleich S, Semmler A, Frieling H, Thumfart L, Muschler M, Hillemacher T, Kornhuber J, Kallweit U, Simon M, Linnebank M (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Epigenomics Future Medicine

Book Volume: 6

Pages Range: 585-91

Journal Issue: 6

DOI: 10.2217/EPI.14.54

Abstract

Altered DNA methylation is associated with important and common pathologies such as cancer. The origin of altered DNA methylation is unknown. The methyl groups for DNA methylation are provided by methionine metabolism. This metabolism is characterized by a high interindividual variability, which is in part explained by genetic variants.In a cohort of 313 individuals derived from a family-based study with index cases of cerebrovascular disease, we analyzed whether global methylation of leukocyte DNA was associated with age, gender, homocysteine plasma levels or functionally relevant genetic variants.We observed an association of the G-allele of the methionine synthase variant c.2756A>G (D919G) with global methylation (% methylation ± 1 SD, AA: 41.3 ± 14.9; AG: 36.4 ± 18.2; GG: 30.8 ± 16.9; F = 4.799; p = 0.009). The methionine synthase variant c.2756A>G is associated with various types of cancer.Our data suggest that an impact on DNA methylation may contribute to the clinical relevance of the methionine synthase variant.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Universitätsspital Zürich (USZ) CH Switzerland (CH) Universitätsklinikum Bonn DE Germany (DE)

How to cite

APA:

Bleich, S., Semmler, A., Frieling, H., Thumfart, L., Muschler, M., Hillemacher, T.,... Linnebank, M. (2014). Genetic variants of methionine metabolism and DNA methylation. Epigenomics, 6(6), 585-91. https://dx.doi.org/10.2217/EPI.14.54

MLA:

Bleich, Stefan, et al. "Genetic variants of methionine metabolism and DNA methylation." Epigenomics 6.6 (2014): 585-91.

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