Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial
Schneider A, Schneider MP, Krieter DH, Genser B, Scharnagl H, Stojakovic T, Wanner C, Drechsler C (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 10
Pages Range: e0128079
Journal Issue: 5
DOI: 10.1371/journal.pone.0128079
Abstract
In patients undergoing maintenance hemodialysis (HD), increased levels of circulating fibroblast growth factor-23 (FGF-23) are independently associated with cardiovascular events and mortality. Interventional strategies aiming to reduce levels of FGF-23 in HD patients are of particular interest. The purpose of the current study was to compare the impact of high-flux versus low-flux HD on circulating FGF-23 levels.We conducted a post-hoc analysis of the MINOXIS study, including 127 dialysis patients randomized to low-flux (n = 62) and high-flux (n = 65) HD for 52 weeks. Patients with valid measures for FGF-23 investigated baseline and after 52 weeks were included.Compared to baseline, a significant increase in FGF-23 levels after one year of low-flux HD was observed (Delta plasma FGF-23: +4026 RU/ml; p < 0.001). In contrast, FGF-23 levels remained stable in the high flux group (Delta plasma FGF-23: +373 RU/ml, p = 0.70). The adjusted difference of the absolute change in FGF-23 levels between the two treatment groups was statistically significant (p < 0.01).Over a period of 12 months, high-flux HD was associated with stable FGF-23 levels, whereas the low-flux HD group showed an increase of FGF-23. However, the implications of the different FGF 23 time-trends in patients on high flux dialysis, as compared to the control group, remain to be explored in specifically designed clinical trials.German Clinical Trials Register (DRKS) DRKS00007612.
Involved external institutions
Germany (DE)How to cite
APA:
Schneider, A., Schneider, M.P., Krieter, D.H., Genser, B., Scharnagl, H., Stojakovic, T.,... Drechsler, C. (2015). Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial. PLoS ONE, 10(5), e0128079. https://dx.doi.org/10.1371/journal.pone.0128079
MLA:
Schneider, Andreas, et al. "Effect of High-Flux Dialysis on Circulating FGF-23 Levels in End-Stage Renal Disease Patients: Results from a Randomized Trial." PLoS ONE 10.5 (2015): e0128079.
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