Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Morris DL, Sheng Y, Zhang Y, Wang YF, Zhu Z, Tombleson P, Chen L, Graham DSC, Bentham J, Roberts AL, Chen R, Zuo X, Wang T, Wen L, Yang C, Liu L, Yang L, Li F, Huang Y, Yin X, Yang S, Rnnblom L, Furnrohr BG, Voll RE, Schett G, Costedoat-Chalumeau N, Gaffney PM, Lau YL, Zhang X, Yang W, Cui Y, Vyse TJ (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Nature Genetics Nature Publishing Group

Book Volume: 48

Pages Range: 940-6

Journal Issue: 8

DOI: 10.1038/ng.3603

Abstract

Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Anhui Medical University CN China (CN) King’s College London GB United Kingdom (GB) University of Hong Kong (HKU) / 香港大學 HK Hong Kong (HK) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) Uppsala University SE Sweden (SE) Hôpital Cochin FR France (FR) Oklahoma Medical Research Foundation (OMRF) US United States (USA) (US)

How to cite

APA:

Morris, D.L., Sheng, Y., Zhang, Y., Wang, Y.-F., Zhu, Z., Tombleson, P.,... Vyse, T.J. (2016). Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. Nature Genetics, 48(8), 940-6. https://doi.org/10.1038/ng.3603

MLA:

Morris, David L., et al. "Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus." Nature Genetics 48.8 (2016): 940-6.

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