Conformations and tautomers of tetracycline

Journal article

Publication Details

Author(s): Othersen O, Beierlein F, Lanig H, Clark T
Journal: Journal of Physical Chemistry B
Publisher: American Chemical Society
Publication year: 2003
Volume: 107
Journal issue: 49
Pages range: 13743-13749
ISSN: 1520-6106
eISSN: 1520-5207


Density functional theory (DFT) has been used to investigate the conformations and tautomeric forms of neutral tetracycline in aqueous solution. The results suggest that the extended conformation is 3-3.5 kcal mol(-1) more stable than the twisted one for equivalent tautomers and that as many as six different tautomeric forms lie within 10 kcal mol(-1) of the most stable one. The energetic preference for the extended conformation is a solvent effect. Calculated infrared, NMR, and UV/vis spectra are used to suggest ways of differentiating between tautomers. and conformations experimentally. It is shown that the (13)C chemical shifts of C4a, C5, and C6 can be used to distinguish between the twisted and extended conformations.

FAU Authors / FAU Editors

Beierlein, Frank Dr.
Clark, Timothy apl. Prof. Dr.
Lanig, Harald PD Dr.
Exzellenz-Cluster Engineering of Advanced Materials

How to cite

Othersen, O., Beierlein, F., Lanig, H., & Clark, T. (2003). Conformations and tautomers of tetracycline. Journal of Physical Chemistry B, 107(49), 13743-13749.

Othersen, Olaf, et al. "Conformations and tautomers of tetracycline." Journal of Physical Chemistry B 107.49 (2003): 13743-13749.


Last updated on 2018-08-08 at 05:41