Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals

Journal article


Publication Details

Author(s): Schulz A, Koester S, Beutel ME, Schaechinger H, Voegele C, Rost S, Rauh M, Michal M
Journal: Psychosomatic Medicine
Publication year: 2015
Volume: 77
Journal issue: 5
Pages range: 506-16
ISSN: 0033-3174


Abstract

Core features of depersonalization/derealization disorder (DPD) are emotional numbing and feelings of disembodiment. Although there are several neurophysiological findings supporting subjective emotional numbing, the psychobiology of disembodiment remains unclear.Heartbeat-evoked potentials (HEPs), which are considered psychophysiological indicators for the cortical representation of afferent signals originating from the cardiovascular system, were assessed in 23 patients with DPD and 24 healthy control individuals during rest and while performing a heartbeat perception task.Absolute HEP amplitudes did not differ between groups. Nevertheless, healthy individuals showed higher HEPs during the heartbeat perception task than during rest, whereas no such effect was found in patients with DPD (p = .031). Patients with DPD had higher total levels of salivary ?-amylase than did healthy individuals (9626.6 [8200.0] versus 5344.3 [3745.8] kU min/l; p = .029), but there were no group differences in cardiovascular measures (heart rate = 76.2 [10.1] versus 74.3 [7.5] beats/min, p = .60; normalized low-frequency heart rate variability = 0.63 [0.15] versus 0.56 [0.15] normalized units, p = .099; low frequency/high frequency ratio = 249.3 [242.7] versus 164.8 [108.8], p = .10), salivary cortisol (57.5 [46.7] versus 55.1 [43.6] nmol min/l, p = .86), or cortisone levels (593.2 [260.3] versus 543.8 [257.1] nmol min/l, p = .52).These results suggest altered cortical representation of afferent signals originating from the cardiovascular system in patients with DPD, which may be associated with higher sympathetic tone. These findings may reflect difficulties of patients with DPD to attend to their actual bodily experiences.


FAU Authors / FAU Editors

Rauh, Manfred Prof. Dr.
Kinder- und Jugendklinik


External institutions with authors

Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Universität Trier
University of Luxembourg


How to cite

APA:
Schulz, A., Koester, S., Beutel, M.E., Schaechinger, H., Voegele, C., Rost, S.,... Michal, M. (2015). Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals. Psychosomatic Medicine, 77(5), 506-16. https://dx.doi.org/10.1097/PSY.0000000000000195

MLA:
Schulz, Andre, et al. "Altered patterns of heartbeat-evoked potentials in depersonalization/derealization disorder: neurophysiological evidence for impaired cortical representation of bodily signals." Psychosomatic Medicine 77.5 (2015): 506-16.

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Last updated on 2018-09-10 at 07:20

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