Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis
Beckervordersandforth R, Zhang CL, Lie DC (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 7
Journal Issue: 10
DOI: 10.1101/cshperspect.a018879
Abstract
Adult-generated dentate granule neurons have emerged as major contributors to hippocampal plasticity. New neurons are generated from neural stem cells through a complex sequence of proliferation, differentiation, and maturation steps. Development of the new neuron is dependent on the precise temporal activity of transcription factors, which coordinate the expression of stage-specific genetic programs. Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli. Understanding transcription factor-mediated control of neuronal development will provide new insights into the mechanisms underlying neurogenesis-dependent plasticity in health and disease.
Authors with CRIS profile
Ruth Beckervordersandforth-Bonk
Lehrstuhl für Biochemie und Pathobiochemie
Dieter Chichung Lie
Professur für Molekulare Medizin mit dem Schwerpunkt Molekulare Bildgebung
Additional Organisation(s)
Involved external institutions
United States (USA) (US)How to cite
APA:
Beckervordersandforth, R., Zhang, C.-L., & Lie, D.C. (2015). Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis. Cold Spring Harbor Perspectives in Biology, 7(10). https://doi.org/10.1101/cshperspect.a018879
MLA:
Beckervordersandforth, Ruth, Chun-Li Zhang, and Dieter Chichung Lie. "Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis." Cold Spring Harbor Perspectives in Biology 7.10 (2015).
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