The pro-angiogenic properties of multi-functional bioactive glass composite scaffolds

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autor(en): Gerhardt LC, Widdows KL, Erol MM, Burch CW, Sanz-Herrera JA, Ochoa I, Stämpfli R, Roqan IS, Gabe S, Ansari T, Boccaccini AR
Zeitschrift: Biomaterials
Verlag: Elsevier
Jahr der Veröffentlichung: 2011
Heftnummer: 32
Seitenbereich: 4096-4108
ISSN: 0142-9612


The angiogenic properties of micron-sized (m-BG) and nano-sized (n-BG) bioactive glass (BG) filled poly(D,L lactide) (PDLLA) composites were investigated. On the basis of cell culture work investigating the secretion of vascular endothelial growth factor (VEGF) by human fibroblasts in contact with composite films (0, 5, 10, 20 wt %), porous 3D composite scaffolds, optimised with respect to the BG filler content capable of inducing angiogenic response, were produced. The in vivo vascularisation of the scaffolds was studied in a rat animal model and quantified using stereological analyses. The prepared scaffolds had high porosities (81-93%), permeability (k = 5.4-8.6 × 10-9 m2) and compressive strength values (0.4-1.6 MPa) all in the range of trabecular bone. On composite films containing 20 wt % m-BG or n-BG, human fibroblasts produced 5 times higher VEGF than on pure PDLLA films. After 8 weeks of implantation, m-BG and n-BG containing scaffolds were well-infiltrated with newly formed tissue and demonstrated higher vascularisation and percentage blood vessel to tissue (11.6-15.1%) than PDLLA scaffolds (8.5%). This work thus shows potential for the regeneration of hard-soft tissue defects and increased bone formation arising from enhanced vascularisation of the construct. © 2011 Elsevier Ltd.

FAU-Autoren / FAU-Herausgeber

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Autor(en) der externen Einrichtung(en)
Eidgenössische Materialprüfungs- und Forschungsanstalt (Empa) / Swiss Federal Laboratories for Materials Science & Technology
Imperial College London / The Imperial College of Science, Technology and Medicine
Istanbul Technical University / İstanbul Teknik Üniversitesi (İTÜ)
King Abdullah University of Science and Technology (KAUST) / جامعة الملك عبد الله للعلوم و التقنية
St. Mark's Hospital
Universidad de Zaragoza
University of Seville / Universidad de Sevilla


Gerhardt, L.-C., Widdows, K.L., Erol, M.M., Burch, C.W., Sanz-Herrera, J.A., Ochoa, I.,... Boccaccini, A.R. (2011). The pro-angiogenic properties of multi-functional bioactive glass composite scaffolds. Biomaterials, 32, 4096-4108.

Gerhardt, Lutz-Christian, et al. "The pro-angiogenic properties of multi-functional bioactive glass composite scaffolds." Biomaterials 32 (2011): 4096-4108.


Zuletzt aktualisiert 2018-08-08 um 05:21