Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium

Journal article

Publication Details

Author(s): Simons K, De Smedt T, Stove C, De Paepe P, Bader M, Nemery B, Vleminckx C, De Cremer K, Van Overmeire I, Fierens S, Mertens B, Göen T, Schettgen T, Van Oyen H, Van Loco J, Van Nieuwenhuyse A
Journal: Environmental Research
Publication year: 2016
Volume: 148
Pages range: 256-63
ISSN: 0013-9351


Following a train derailment, several tons of acrylonitrile (ACN) exploded, inflamed and part of the ACN ended up in the sewage system of the village of Wetteren. More than 2000 residents living in the close vicinity of the accident and along the sewage system were evacuated. A human biomonitoring study of the adduct N-2-cyanoethylvaline (CEV) was carried out days 14-21 after the accident.(1) To describe the short-term health effects that were reported by the evacuated residents following the train accident, and (2) to explore the association between the CEV concentrations, extrapolated at the time of the accident, and the self-reported short-term health effects.Short-term health effects were reported in a questionnaire (n=191). An omnibus test of independence was used to investigate the association between the CEV concentrations and the symptoms. Dose-response relationships were quantified by Generalized Additive Models (GAMs).The most frequently reported symptoms were local symptoms of irritation. In non-smokers, dose-dependency was observed between the CEV levels and the self-reporting of irritation (p=0.007) and nausea (p=0.007). Almost all non-smokers with CEV concentrations above 100pmol/g globin reported irritation symptoms. Both absence and presence of symptoms was reported by non-smokers with CEV concentrations below the reference value and up to 10 times the reference value. Residents who visited the emergency services reported more symptoms. This trend was seen for the whole range of CEV concentrations, and thus independently of the dose.The present study is one of the first to relate exposure levels to a chemical released during a chemical incident to short-term (self-reported) health effects. A dose-response relation was observed between the CEV concentrations and the reporting of short-term health effects in the non-smokers. Overall, the value of self-reported symptoms to assess exposure showed to be limited. The results of this study confirm that a critical view should be taken when considering self-reported health complaints and that ideally biomarkers are monitored to allow an objective assessment of exposure.

FAU Authors / FAU Editors

Göen, Thomas Prof. Dr.
Lehrstuhl für Arbeits- und Sozialmedizin

External institutions with authors

Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Scientific Institute of Public Health
Universiteit Gent (UGent) / Ghent University
University Hospital Ghent

How to cite

Simons, K., De Smedt, T., Stove, C., De Paepe, P., Bader, M., Nemery, B.,... Van Nieuwenhuyse, A. (2016). Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium. Environmental Research, 148, 256-63.

Simons, K., et al. "Short-term health effects in the general population following a major train accident with acrylonitrile in Belgium." Environmental Research 148 (2016): 256-63.


Last updated on 2018-09-10 at 07:17