The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Zaiss M, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, Paerewijck O, Geldhof P, Mccoy KD, Macpherson AJ, Croese J, Giacomin PR, Loukas A, Junt T, Marsland BJ, Harris NL (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Immunity Elsevier

Publisher: Elsevier (Cell Press)

Book Volume: 43

Pages Range: 998-1010

Journal Issue: 5

DOI: 10.1016/j.immuni.2015.09.012

Abstract

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the local microbiota. We report that chronic infection with the murine helminth Heligmosomoides polygyrus bakeri (Hpb) altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production. Transfer of the Hpb-modified microbiota alone was sufficient to mediate protection against allergic asthma. The helminth-induced anti-inflammatory cytokine secretion and regulatory T cell suppressor activity that mediated the protection required the G protein-coupled receptor (GPR)-41. A similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.

Authors with CRIS profile

Mario Zaiss Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

École Polytechnique Fédérale de Lausanne (EPFL) CH Switzerland (CH) University of Geneva / Université de Genève (UNIGE) CH Switzerland (CH) Wellcome Trust Sanger Institute - Genome Research Limited GB United Kingdom (GB) Universiteit Gent (UGent) / Ghent University BE Belgium (BE) Inselspital, Universitätsspital Bern CH Switzerland (CH) The Prince Charles Hospital AU Australia (AU) James Cook University AU Australia (AU) Novartis AG CH Switzerland (CH) Université de Lausanne (UNIL) CH Switzerland (CH)

How to cite

APA:

Zaiss, M., Rapin, A., Lebon, L., Dubey, L.K., Mosconi, I., Sarter, K.,... Harris, N.L. (2015). The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity, 43(5), 998-1010. https://dx.doi.org/10.1016/j.immuni.2015.09.012

MLA:

Zaiss, Mario, et al. "The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation." Immunity 43.5 (2015): 998-1010.

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