Peri-implant defect regeneration in the diabetic pig: A preclinical study

Journal article

Publication Details

Author(s): von Wilmowsky C, Schlegel A, Baran C, Nkenke E, Neukam FW, Moest T
Journal: Journal of Cranio-Maxillofacial Surgery
Publication year: 2016
Volume: 44
Journal issue: 7
Pages range: 827-34
ISSN: 1010-5182


The study aims to establish a peri-implant dehiscence-type bone defect in a diabetic animal model of human bone repair and to quantify the influence of diabetes on peri-implant bone regeneration.Experimental diabetes was induced in three domestic pigs by streptozotocin. Three animals served as healthy controls. After 12 months four standardized peri-implant dehiscence bone defects were surgically created in the ramus mandibulae. The animals were sacrificed after 90 days. Samples were histologically analyzed to quantify new bone height (NBH), bone-to-implant-contact (BIC), area of newly formed bone (NFB), bone-density (BD), and bone mineralization (BM) in the prepared defect (-D) and in a local control region (-L).After 90 days, diabetic animals revealed a significantly lower BIC (p = 0.037) and BD (p = 0.041) in the defect area (-D). NBH and BM-D differences within the groups were not significant (p > 0.05). Significant more NFB was measured in the healthy control group (p = 0.046). In the region of local bone BIC-L was significant less in the diabetic group (p = 0.028). In the local control region BD-L and BM-L was lower in the diabetic group compared to the healthy control animals (p > 0.05).Histological evidence indicates impaired peri-implant defect regeneration in a diabetic animal model.

FAU Authors / FAU Editors

Neukam, Friedrich Wilhelm Prof. Dr. Dr.
Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie
Schlegel, Andreas Prof. Dr. Dr.
Medizinische Fakultät
von Wilmowsky, Cornelius PD Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik

External institutions with authors

Medizinische Universität Wien

How to cite

von Wilmowsky, C., Schlegel, A., Baran, C., Nkenke, E., Neukam, F.W., & Moest, T. (2016). Peri-implant defect regeneration in the diabetic pig: A preclinical study. Journal of Cranio-Maxillofacial Surgery, 44(7), 827-34.

von Wilmowsky, Cornelius, et al. "Peri-implant defect regeneration in the diabetic pig: A preclinical study." Journal of Cranio-Maxillofacial Surgery 44.7 (2016): 827-34.


Last updated on 2018-09-10 at 02:26