Gender- and site-specific differences of colorectal neoplasia relate to vitamin D

Aigner E, Stadlmayr A, Huber-Schoenauer U, Zwerina J, Husar-Memmer E, Niederseer D, Trauner M, Heuberger A, Hohla F, Schett G, Patsch W, Datz C (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Alimentary Pharmacology & Therapeutics Wiley-Blackwell

Book Volume: 40

Pages Range: 1341-8

Journal Issue: 11-12

DOI: 10.1111/apt.12981

Abstract

The effect of vitamin D on colorectal adenomas may vary with regard to gender, localisation and histological type of the lesion.To define the role of vitamin D and gender in a Caucasian cohort of subjects undergoing screening colonoscopy after consideration of established risk factors.One thousand five hundred and thirty-two subjects (813 males, 58.8 ± 9.7 years; 719 females, 59.7 ± 10.7 years) were allocated to tertiles of 25-hydroxyvitamin D3 [25(OH)D3 ] serum concentrations. The number, localisation, size and histology of the detected colonic lesions were recorded.Among men, no association was found between vitamin D and the total number, size and histological stage of adenomas at any site. In female subjects, less women with adenomas were found in the highest vitamin D tertile (N = 42/239; 17.2%) as compared to the low vitamin D group (N = 60/240; 25.0%; P = 0.035). In particular, the number of women with adenomas in the proximal colon was significantly lower in the highest tertile (N = 21/239, 8.8%) compared to the low vitamin D group (N = 41/240; 17.1%; P = 0.007). The rates at other sites were not different. The inverse association of vitamin D serum concentrations with the presence of adenomas in the proximal colon was maintained after adjustment for potential confounders. In 80 women on vitamin D supplementation, the rate of adenomas was lower compared to those not on supplementation (3/80; 3.8%; vs. 90/719; 12.5%; P = 0.016).A potential preventive effect of vitamin D on colorectal adenomas was found in the proximal colon in women. This observation is supported by further decrease of lesions in the proximal colon of women on vitamin D supplementation.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Paracelsus Medizinische Privatuniversität AT Austria (AT) Hanusch-Krankenhaus AT Austria (AT) Medizinische Universität Wien AT Austria (AT)

How to cite

APA:

Aigner, E., Stadlmayr, A., Huber-Schoenauer, U., Zwerina, J., Husar-Memmer, E., Niederseer, D.,... Datz, C. (2014). Gender- and site-specific differences of colorectal neoplasia relate to vitamin D. Alimentary Pharmacology & Therapeutics, 40(11-12), 1341-8. https://doi.org/10.1111/apt.12981

MLA:

Aigner, E., et al. "Gender- and site-specific differences of colorectal neoplasia relate to vitamin D." Alimentary Pharmacology & Therapeutics 40.11-12 (2014): 1341-8.

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