ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies
Lecour S, Botker HE, Condorelli G, Davidson SM, Garcia-Dorado D, Engel F, Ferdinandy P, Heusch G, Madonna R, Ovize M, Ruiz-Meana M, Schulz R, Sluijter JPG, Van Laake LW, Yellon DM, Hausenloy DJ (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 104
Pages Range: 399-411
Journal Issue: 3
DOI: 10.1093/cvr/cvu225
Abstract
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. In this regard, although a large number of novel cardioprotective therapies discovered in the research laboratory have been investigated in the clinical setting, only a few of these have been demonstrated to improve clinical outcomes. One potential reason for this lack of success may have been the failure to thoroughly assess the cardioprotective efficacy of these novel therapies in suitably designed preclinical experimental animal models. Therefore, the aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to provide recommendations for improving the preclinical assessment of novel cardioprotective therapies discovered in the research laboratory, with the aim of increasing the likelihood of success in translating these new treatments into improved clinical outcomes.
Authors with CRIS profile
Involved external institutions
University of Cape Town (UCT)
South Africa (ZA)
Aarhus University Hospital / Aarhus Universitetshospital
Denmark (DK)
Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy
Italy (IT)
University College London (UCL)
United Kingdom (GB)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Spain (ES)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
Universitätsklinikum Essen
Germany (DE)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
Université Claude Bernard Lyon 1 (UCB)
France (FR)
Justus-Liebig-Universität Gießen
Germany (DE)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
South Africa (ZA)
Aarhus University Hospital / Aarhus Universitetshospital
Denmark (DK)
Consiglio Nazionale delle Ricerche (CNR) / National Research Council of Italy
Italy (IT)
University College London (UCL)
United Kingdom (GB)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron
Spain (ES)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
Universitätsklinikum Essen
Germany (DE)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
Université Claude Bernard Lyon 1 (UCB)
France (FR)
Justus-Liebig-Universität Gießen
Germany (DE)
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
How to cite
APA:
Lecour, S., Botker, H.E., Condorelli, G., Davidson, S.M., Garcia-Dorado, D., Engel, F.,... Hausenloy, D.J. (2014). ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies. Cardiovascular Research, 104(3), 399-411. https://doi.org/10.1093/cvr/cvu225
MLA:
Lecour, Sandrine, et al. "ESC Working Group Cellular Biology of the Heart: Position Paper: improving the preclinical assessment of novel cardioprotective therapies." Cardiovascular Research 104.3 (2014): 399-411.
BibTeX: Download