Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications
Misra SK, Ansari TI, Valappil SP, Mohn D, Philip SE, Stark WJ, Roy I, Knowles JC, Salih V, Boccaccini AR (2010)
Publication Type: Journal article
Publication year: 2010
Journal
Publisher: Elsevier
Book Volume: 31
Pages Range: 2806-2815
DOI: 10.1016/j.biomaterials.2009.12.045
Abstract
Poly(3-hydroxybutyrate) (P(3HB)) foams exhibiting highly interconnected porosity (85% porosity) were prepared using a unique combination of solvent casting and particulate leaching techniques by employing commercially available sugar cubes as porogen. Bioactive glass (BG) particles of 45S5 Bioglass® grade were introduced in the scaffold microstructure, both in micrometer ((m-BG), <5 μm) and nanometer ((n-BG), 30 nm) sizes. The in vitro bioactivity of the P(3HB)/BG foams was confirmed within 10 days of immersion in simulated body fluid and the foams showed high level of protein adsorption. The foams interconnected porous microstructure proved to be suitable for MG-63 osteoblast cell attachment and proliferation. The foams implanted in rats as subcutaneous implants resulted in a non-toxic and foreign body response after one week of implantation. In addition to showing bioactivity and biocompatibility, the P(3HB)/BG composite foams also exhibited bactericidal properties, which was tested on the growth of Staphylococcus aureus. An attempt was made at developing multifunctional scaffolds by incorporating, in addition to BG, selected concentrations of Vitamin E or/and carbon nanotubes. P(3HB) scaffolds with multifunctionalities (viz. bactericidal, bioactive, electrically conductive, antioxidative behaviour) were thus produced, which paves the way for next generation of advanced scaffolds for bone tissue engineering. © 2009 Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Involved external institutions
Imperial College London / The Imperial College of Science, Technology and Medicine
United Kingdom (GB)
The Griffin Institute - Northwick Park Institute for Medical Research (NPIMR)
United Kingdom (GB)
The University of Liverpool
United Kingdom (GB)
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
University of Westminster
United Kingdom (GB)
University College London (UCL)
United Kingdom (GB)
United Kingdom (GB)
The Griffin Institute - Northwick Park Institute for Medical Research (NPIMR)
United Kingdom (GB)
The University of Liverpool
United Kingdom (GB)
Eidgenössische Technische Hochschule Zürich (ETHZ) / Swiss Federal Institute of Technology in Zurich
Switzerland (CH)
University of Westminster
United Kingdom (GB)
University College London (UCL)
United Kingdom (GB)
How to cite
APA:
Misra, S.K., Ansari, T.I., Valappil, S.P., Mohn, D., Philip, S.E., Stark, W.J.,... Boccaccini, A.R. (2010). Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications. Biomaterials, 31, 2806-2815. https://dx.doi.org/10.1016/j.biomaterials.2009.12.045
MLA:
Misra, Superb K., et al. "Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications." Biomaterials 31 (2010): 2806-2815.
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