Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring

Fattori G, Saito N, Seregni M, Kaderka R, Pella A, Constantinescu A, Riboldi M, Steidl P, Cerveri P, Bert C, Durante M, Baroni G (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Technology in Cancer Research & Treatment Adenine Press

Book Volume: 13

Pages Range: 517-28

Journal Issue: 6

DOI: 10.7785/tcrtexpress.2013.600275

Abstract

The integrated use of optical technologies for patient monitoring is addressed in the framework of time-resolved treatment delivery for scanned ion beam therapy. A software application has been designed to provide the therapy control system (TCS) with a continuous geometrical feedback by processing the external surrogates tridimensional data, detected in real-time via optical tracking. Conventional procedures for phase-based respiratory phase detection were implemented, as well as the interface to patient specific correlation models, in order to estimate internal tumor motion from surface markers. In this paper, particular attention is dedicated to the quantification of time delays resulting from system integration and its compensation by means of polynomial interpolation in the time domain. Dedicated tests to assess the separate delay contributions due to optical signal processing, digital data transfer to the TCS and passive beam energy modulation actuation have been performed. We report the system technological commissioning activities reporting dose distribution errors in a phantom study, where the treatment of a lung lesion was simulated, with both lateral and range beam position compensation. The zero-delay systems integration with a specific active scanning delivery machine was achieved by tuning the amount of time prediction applied to lateral (14.61 ± 0.98 ms) and depth (34.1 ± 6.29 ms) beam position correction signals, featuring sub-millimeter accuracy in forward estimation. Direct optical target observation and motion phase (MPh) based tumor motion discretization strategies were tested, resulting in 20.3(2.3)% and 21.2(9.3)% median (IQR) percentual relative dose difference with respect to static irradiation, respectively. Results confirm the technical feasibility of the implemented strategy towards 4D treatment delivery, with negligible percentual dose deviations with respect to static irradiation.

Authors with CRIS profile

Christoph Bert Professur für Med. Strahlenphysik

Involved external institutions

Politecnico di Milano IT Italy (IT) Centro Nazionale di Adroterapia Oncologica (CNAO) IT Italy (IT) GSI Helmholtzzentrum für Schwerionenforschung GmbH DE Germany (DE)

How to cite

APA:

Fattori, G., Saito, N., Seregni, M., Kaderka, R., Pella, A., Constantinescu, A.,... Baroni, G. (2014). Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring. Technology in Cancer Research & Treatment, 13(6), 517-28. https://dx.doi.org/10.7785/tcrtexpress.2013.600275

MLA:

Fattori, Giovanni, et al. "Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring." Technology in Cancer Research & Treatment 13.6 (2014): 517-28.

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