IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy
Mousset S, Koch S, Mousset S, Graser A, Reppert S, Uebel C, Reinhardt C, Zimmermann T, Rieker R, Lehr HA, Finotto S (2013)
Publication Type: Journal article
Publication year: 2013
Journal
Original Authors: Koch S, Mousset S, Graser A, Reppert S, Ubel C, Reinhardt C, Zimmermann T, Rieker R, Lehr HA, Finotto S
Publisher: Nature Publishing Group: Open Access Journals - Option B
Book Volume: 3
Pages Range: 1754
DOI: 10.1038/srep01754
Abstract
IL-6 plays a central role in supporting pathological TH2 and TH17 cell development and inhibiting the protective T regulatory cells in allergic asthma. TH17 cells have been demonstrated to regulate allergic asthma in general and T-bet-deficiency-induced asthma in particular. Here we found an inverse correlation between T-bet and Il-6 mRNA expression in asthmatic children. Moreover, experimental subcutaneous immunotherapy (SIT) in T-bet((-/-)) mice inhibited IL-6, IL-21R and lung TH17 cells in a setting of asthma. Finally, local delivery of an anti-IL-6R antibody in T-bet((-/-)) mice resulted in the resolution of this allergic trait. Noteworthy, BATF, crucial for the immunoglobulin-class-switch and TH2,TH17 development, was found down-regulated in the lungs of T-bet((-/-)) mice after SIT and after treatment with anti-IL-6R antibody, indicating a critical role of IL-6 in controlling BATF/IRF4 integrated functions in TH2, TH17 cells and B cells also in a T-bet independent fashion in allergic asthma.
Authors with CRIS profile
Stephanie Mousset
Lehrstuhl für Biochemie
Sonja Koch
Department of Molecular Pneumology
Anna Graser
Department of Molecular Pneumology
Theodor Zimmermann
Medizinische Fakultät
Susetta Neurath-Finotto
Department of Molecular Pneumology
Involved external institutions
Switzerland (CH)How to cite
APA:
Mousset, S., Koch, S., Mousset, S., Graser, A., Reppert, S., Uebel, C.,... Finotto, S. (2013). IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy. Scientific Reports, 3, 1754. https://doi.org/10.1038/srep01754
MLA:
Mousset, Stephanie, et al. "IL-6 activated integrated BATF/IRF4 functions in lymphocytes are T-bet-independent and reversed by subcutaneous immunotherapy." Scientific Reports 3 (2013): 1754.
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