Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms
Duran I, Goebell P, Papazisis K, Ravaud A, Weichhart T, Antonio Rodriguez-Portal J, Budde K (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 13
Pages Range: 361-72
Journal Issue: 3
DOI: 10.1517/14740338.2014.888056
Abstract
Inhibitors of the mammalian target of rapamycin (mTOR) are widely utilized in cancer and transplantation, with increased use of these agents expected in future years. Although generally well tolerated, drug-induced pneumonitis (DIP) has been described as a class effect associated with these compounds, especially at higher doses. This toxicity is observed in about a third of cancer patients, although only around 10% will have symptoms necessitating treatment. Clinical DIP can be effectively managed by early recognition and prompt intervention, including dose reduction and/or treatment cessation. However, little is known about the pathophysiology of this entity and its best management.This article will review current understanding of the mechanism of DIP, as well as the clinical impact and management of this toxicity in cancer patients treated with mTOR inhibitors. It also provides direction for future research.Although guidelines on the management of mTOR inhibitor-associated DIP in cancer patients have been published, these do not always concur or cover all management aspects. Education of patients and healthcare professionals is a key component in managing mTOR inhibitor therapy; assessing the history of pulmonary conditions before the initiation of such a therapy is also essential. Updated diagnostic criteria for pneumonitis might improve our knowledge in the future.
Authors with CRIS profile
Involved external institutions
Hospitales Universitarios Virgen Macarena y Virgen del Rocío
Spain (ES)
Euromedica Geniki Kliniki of Thessaloniki
Greece (GR)
Centre Hospitalier Universitaire de Bordeaux / CHU Bordeaux
France (FR)
Medizinische Universität Wien
Austria (AT)
Charité - Universitätsmedizin Berlin
Germany (DE)
Spain (ES)
Euromedica Geniki Kliniki of Thessaloniki
Greece (GR)
Centre Hospitalier Universitaire de Bordeaux / CHU Bordeaux
France (FR)
Medizinische Universität Wien
Austria (AT)
Charité - Universitätsmedizin Berlin
Germany (DE)
How to cite
APA:
Duran, I., Goebell, P., Papazisis, K., Ravaud, A., Weichhart, T., Antonio Rodriguez-Portal, J., & Budde, K. (2014). Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms. Expert Opinion on Drug Safety, 13(3), 361-72. https://doi.org/10.1517/14740338.2014.888056
MLA:
Duran, Ignacio, et al. "Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms." Expert Opinion on Drug Safety 13.3 (2014): 361-72.
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