Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence

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Details zur Publikation

Autor(en): Zierk J, Arzideh F, Rechenauer T, Haeckel R, Rascher W, Metzler M, Rauh M
Zeitschrift: Clinical Chemistry
Jahr der Veröffentlichung: 2015
Band: 61
Heftnummer: 7
Seitenbereich: 964-73
ISSN: 0009-9147


Pediatric laboratory test results must be interpreted in the context of interindividual variation and age- and sex-dependent dynamics. Reference intervals as presently defined for separate age groups can only approximate the age-related dynamics encountered in pediatrics. Continuous reference intervals from birth to adulthood are not available for most laboratory analytes because of the ethical and practical constraints of defining reference intervals using a population of healthy community children. We applied an indirect method to generate continuous reference intervals for 22 hematologic and biochemical analytes by analyzing clinical laboratory data from blood samples taken during clinical care of patients.We included samples from 32 000 different inpatients and outpatients (167 000 samples per analyte) from a German pediatric tertiary care center. Measurements were performed on a Sysmex-XE 2100 and a Cobas Integra 800 during clinical care over a 6-year period. The distribution of samples considered normal was estimated with an established indirect statistical approach and used for the calculation of reference intervals.We provide continuous reference intervals from birth to adulthood for 9 hematology analytes (hemoglobin, hematocrit, red cell indices, red cell count, red cell distribution width, white cell count, and platelet count) and 13 biochemical analytes (sodium, chloride, potassium, calcium, magnesium, phosphate, creatinine, aspartate transaminase, alanine transaminase, ?-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase, and total protein).Continuous reference intervals capture the population changes in laboratory analytes during pediatric development more accurately than age groups. After local validation, the reference intervals provided should allow a more precise consideration of these dynamics in clinical decision making.

FAU-Autoren / FAU-Herausgeber

Metzler, Markus PD Dr.
Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie
Rascher, Wolfgang Prof. Dr. med.
Lehrstuhl für Kinderheilkunde
Rauh, Manfred Prof. Dr.
Kinder- und Jugendklinik
Rechenauer, Tobias Dr. med.
Kinder- und Jugendklinik
Zierk, Jakob Dr. med.
Kinder- und Jugendklinik

Autor(en) der externen Einrichtung(en)
Klinikverbund Bremen
Universität Bremen


Zierk, J., Arzideh, F., Rechenauer, T., Haeckel, R., Rascher, W., Metzler, M., & Rauh, M. (2015). Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence. Clinical Chemistry, 61(7), 964-73.

Zierk, Jakob, et al. "Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence." Clinical Chemistry 61.7 (2015): 964-73.


Zuletzt aktualisiert 2018-09-10 um 02:23