Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence

Zierk J, Arzideh F, Rechenauer T, Haeckel R, Rascher W, Metzler M, Rauh M (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Clinical Chemistry American Association for Clinical Chemistry

Book Volume: 61

Pages Range: 964-73

Journal Issue: 7

DOI: 10.1373/clinchem.2015.239731

Abstract

Pediatric laboratory test results must be interpreted in the context of interindividual variation and age- and sex-dependent dynamics. Reference intervals as presently defined for separate age groups can only approximate the age-related dynamics encountered in pediatrics. Continuous reference intervals from birth to adulthood are not available for most laboratory analytes because of the ethical and practical constraints of defining reference intervals using a population of healthy community children. We applied an indirect method to generate continuous reference intervals for 22 hematologic and biochemical analytes by analyzing clinical laboratory data from blood samples taken during clinical care of patients.We included samples from 32 000 different inpatients and outpatients (167 000 samples per analyte) from a German pediatric tertiary care center. Measurements were performed on a Sysmex-XE 2100 and a Cobas Integra 800 during clinical care over a 6-year period. The distribution of samples considered normal was estimated with an established indirect statistical approach and used for the calculation of reference intervals.We provide continuous reference intervals from birth to adulthood for 9 hematology analytes (hemoglobin, hematocrit, red cell indices, red cell count, red cell distribution width, white cell count, and platelet count) and 13 biochemical analytes (sodium, chloride, potassium, calcium, magnesium, phosphate, creatinine, aspartate transaminase, alanine transaminase, ?-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase, and total protein).Continuous reference intervals capture the population changes in laboratory analytes during pediatric development more accurately than age groups. After local validation, the reference intervals provided should allow a more precise consideration of these dynamics in clinical decision making.

Authors with CRIS profile

Jakob Zierk Department of Paediatrics and Adolescent Medicine Tobias Rechenauer Department of Paediatrics and Adolescent Medicine Wolfgang Rascher Lehrstuhl für Kinder- und Jugendmedizin Markus Metzler Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie Manfred Rauh Department of Paediatrics and Adolescent Medicine

Involved external institutions

Klinikverbund Bremen (Gesundheit Nord) DE Germany (DE) Universität Bremen DE Germany (DE)

How to cite

APA:

Zierk, J., Arzideh, F., Rechenauer, T., Haeckel, R., Rascher, W., Metzler, M., & Rauh, M. (2015). Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence. Clinical Chemistry, 61(7), 964-73. https://doi.org/10.1373/clinchem.2015.239731

MLA:

Zierk, Jakob, et al. "Age- and sex-specific dynamics in 22 hematologic and biochemical analytes from birth to adolescence." Clinical Chemistry 61.7 (2015): 964-73.

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