Algorithmic Summaries of Perioperative Blood Pressure Fluctuations

Journal article

Publication Details

Author(s): Toddenroth D, Ganslandt T, Drescher C, Weith T, Prokosch HU, Schüttler J, Münster T
Journal: Studies in health technology and informatics
Publication year: 2016
Volume: 228
Pages range: 532-6
ISSN: 0926-9630


Automated perioperative measurements such as cardiovascular monitoring data are commonly compared to established upper and lower thresholds, but could also allow for more complex interpretations. Analyzing such time series in extensive electronic medical records for research purposes may itself require customized automation, so we developed a set of algorithms for quantifying different aspects of temporal fluctuations. We implemented conventional measures of dispersion, summaries of absolute gradients between successive values, and Poincaré plots. We aggregated the severity and duration of hypotensive episodes by calculating the average area under different mean arterial pressure (MAP) thresholds. We applied these methods to 30,452 de-identified MAP series, and analyzed the similarity between alternative indices via hierarchical clustering. To explore the potential utility of these propositional metrics, we computed their statistical association with presumed complications due to cardiovascular instability. We observed that hierarchical clustering reliably segregated features that had been designed to quantify dissimilar aspects. Summaries of temporary hypotension turned out to be significantly increased among patient subgroups with subsequent signs of a complicated recovery. These associations were even stronger for measures that were specifically geared to capturing short-term MAP variability. These observations suggest the potential capability of our proposed algorithms for quantifying heterogeneous aspects of short-term MAP fluctuations. Future research might also target a wider selection of outcomes and other attributes that may be subject to intraoperative variability.

FAU Authors / FAU Editors

Fehd, Caroline
Lehrstuhl für Medizinische Informatik
Münster, Tino Prof. Dr.
Anästhesiologische Klinik
Prokosch, Hans-Ulrich Prof. Dr.
Lehrstuhl für Medizinische Informatik
Schüttler, Jürgen Prof. Dr.
Lehrstuhl für Anästhesiologie
Toddenroth, Dennis Dr.
Lehrstuhl für Medizinische Informatik
Weith, Thomas
Anästhesiologische Klinik

How to cite

Toddenroth, D., Ganslandt, T., Drescher, C., Weith, T., Prokosch, H.-U., Schüttler, J., & Münster, T. (2016). Algorithmic Summaries of Perioperative Blood Pressure Fluctuations. Studies in health technology and informatics, 228, 532-6.

Toddenroth, Dennis, et al. "Algorithmic Summaries of Perioperative Blood Pressure Fluctuations." Studies in health technology and informatics 228 (2016): 532-6.


Last updated on 2018-09-10 at 02:23