Perturbed development of striatal dopamine transporters in fatty versus lean Zucker rats: a follow-up small animal PET study

Journal article


Publication Details

Author(s): Cumming P, Maschauer S, Riss P, Grill E, Pischetsrieder M, Kuwert T, Prante O
Journal: Molecular Imaging and Biology
Publisher: Springer Verlag (Germany)
Publication year: 2015
Volume: 17
Pages range: 521-528
ISSN: 1536-1632


Abstract


Purpose: Post-synaptic dopamine D2/3 receptors are reduced in animal models of obesity, and in obese humans, concordant with similar findings in habitual drug users. However, corresponding pre-synaptic changes in brain dopamine are less documented in obesity models. Therefore, we used positron emission tomography (PET) with the dopamine transporter (DAT) ligand N-(3-[18F]fluoropropyl)-2-β-carbomethoxy-3-β-(4′-methylphenyl) tropane ([18F]FP-CMT) to test the hypothesis that DAT availability is attenuated in adult fatty Zucker (FZ) rats versus lean littermates (LZ).



FAU Authors / FAU Editors

Maschauer, Simone PD Dr.
Nuklearmedizinische Klinik
Pischetsrieder, Monika Prof. Dr.
Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)


Additional Organisation
Emil-Fischer-Zentrum (Emil Fischer Center)


How to cite

APA:
Cumming, P., Maschauer, S., Riss, P., Grill, E., Pischetsrieder, M., Kuwert, T., & Prante, O. (2015). Perturbed development of striatal dopamine transporters in fatty versus lean Zucker rats: a follow-up small animal PET study. Molecular Imaging and Biology, 17, 521-528. https://dx.doi.org/10.1007/s11307-014-0811-7

MLA:
Cumming, Paul, et al. "Perturbed development of striatal dopamine transporters in fatty versus lean Zucker rats: a follow-up small animal PET study." Molecular Imaging and Biology 17 (2015): 521-528.

BibTeX: 

Last updated on 2018-19-04 at 02:47