Relevance of sonography for botulinum toxin treatment of cervical dystonia: an expert statement
Schramm A, Baeumer T, Fietzek U, Heitmann S, Walter U, Jost WH (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 122
Pages Range: 1457-63
Journal Issue: 10
DOI: 10.1007/s00702-014-1356-2
Abstract
Botulinum neurotoxin A (BoNT A) is the first-line treatment for cervical dystonia. However, although BoNT A has a favorable safety profile and is effective in the majority of patients, in some cases the treatment outcome is disappointing or side effects occur when higher doses are used. It is likely that in such cases either the target muscles were not injected accurately or unintended weakness of non-target muscles occurred. It has been demonstrated in clinical trials for spastic movement disorders that sonography-guided BoNT A injections could improve treatment outcome. As the published evidence for a benefit of sonography-guided BoNT injection in patients with cervical dystonia is scarce, it is the aim of this review to discuss the relevance of sonography in this indication and provide a statement from clinical experts for its use. The clear advantage of sonography-guided injections is non-invasive, real-time visualization of the targeted muscle, thus improving the precision of injections and potentially the treatment outcomes as well as avoiding adverse effects. Other imaging techniques are of limited value due to high costs, radiation exposure or non-availability in clinical routine. In the hands of a trained injector, sonography is a quick and non-invasive imaging technique. Novel treatment concepts of cervical dystonia considering the differential contributions of distinct cranial and cervical muscles can reliably be implemented only by use of imaging-guided injection protocols.
Involved external institutions
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Universität Rostock
Germany (DE)
Deutsche Klinik für Diagnostik
Germany (DE)
Schön Kliniken
Germany (DE)
Universität zu Lübeck
Germany (DE)
Germany (DE)
Universität Rostock
Germany (DE)
Deutsche Klinik für Diagnostik
Germany (DE)
Schön Kliniken
Germany (DE)
Universität zu Lübeck
Germany (DE)
How to cite
APA:
Schramm, A., Baeumer, T., Fietzek, U., Heitmann, S., Walter, U., & Jost, W.H. (2015). Relevance of sonography for botulinum toxin treatment of cervical dystonia: an expert statement. Journal of Neural Transmission, 122(10), 1457-63. https://doi.org/10.1007/s00702-014-1356-2
MLA:
Schramm, Axel, et al. "Relevance of sonography for botulinum toxin treatment of cervical dystonia: an expert statement." Journal of Neural Transmission 122.10 (2015): 1457-63.
BibTeX: Download