Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror?T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung

Balabko L, Andreev K, Burmann N, Schubert M, Mathews M, Trufa D, Reppert S, Rau T, Schicht M, Sirbu H, Hartmann A, Finotto S (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 4

Pages Range: 7396

DOI: 10.1038/srep07396

Abstract

Here we describe increased expression of IL6R in the tumoural region of lung tissue from patients affected by lung adenocarcinoma as compared to squamous cell lung carcinoma. Moreover, here we found increased IL6R in the tumour free part of the lung. By using a murine model of lung adenocarcinoma, we discovered that few lung tumour cells expressed IL-6R and CD4+CD25+Foxp-3+ T regulatory cells down-regulated IL-6R in the tumour bearing lungs. Downstream of IL-6R, the Th17 lineage-specification factors: Signal transducer and activator of transcription 3 (STAT3), Basic leucine zipper transcription factor, BATF and a protein encoded by the RORC in human (RAR-related orphan receptor C) (ROR?T), were also found induced in the tumoural region of lung tissue from patients affected by lung adenocarcinoma as compared to those carrying squamous cell carcinoma. Moreover, pSTAT3 protein was found phosphorylated and auto-phosphorylated in the tumoural region of patients with adeno cell carcinoma of the lung as compared to the tumoural region of patients with squamous cell carcinoma of the lung. Intranasal application of anti-IL-6R antibodies in a murine model of lung adenocarcinoma, induced T regulatory cell markers such as Foxp3, Ctla4, Icos, Il10, Il21, Folr4 and Lag3 and inhibited Rorc in lung adenocarcinoma.

Authors with CRIS profile

Liubov Balabko Professur für Molekulare Pneumologie Katerina Andreev Professur für Experimentelle Immuntherapie Denis Trufa Department of Thoracic Surgery Martin Schicht Lehrstuhl für Funktionelle und Klinische Anatomie Horia Sirbu Department of Thoracic Surgery Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Susetta Neurath-Finotto Department of Molecular Pneumology

How to cite

APA:

Balabko, L., Andreev, K., Burmann, N., Schubert, M., Mathews, M., Trufa, D.,... Finotto, S. (2014). Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror?T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. Scientific Reports, 4, 7396. https://dx.doi.org/10.1038/srep07396

MLA:

Balabko, Liubov, et al. "Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror?T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung." Scientific Reports 4 (2014): 7396.

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