Treatment algorithm for metastatic renal cell carcinoma--recommendations based on evidence and clinical practice
Bergmann L, Beck J, Bothe K, Brinkmann OA, Buse S, Goebell P, Gruenwald V, Holzapfel K, Kuebler H, Marschner NW, Mickischk G, Schultze-Seemann W, Siebels M, Siemer S, Stoerkel S, Gschwend JE (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 37
Pages Range: 136-41
Journal Issue: 3
DOI: 10.1159/000360179
Abstract
Until a few years ago, the treatment options for metastatic renal cell cancer (mRCC) were very limited. The growing understanding of the molecular pathomechanisms underlying RCC allowed the development of new treatment approaches. Meanwhile, several approved target-oriented substances from different drug classes are available for mRCC. The mechanism of action of vascular endothelial growth factor (VEGF) and VEGF receptor or mTOR inhibition is well documented by phase III trials and reflected in the current guidelines. However, no predictive biomarkers have been identified in mRCC so far to demonstrate a benefit by a specific compound in an individual patient. Meanwhile, the sequential use of 'targeted therapies' in mRCC has been established as standard treatment. The optimal sequence of available agents is still unclear. A German RCC expert panel discussed and developed an algorithm for the choices of first- and second-line treatment in mRCC based on established clinical criteria.
Authors with CRIS profile
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
HELIOS Kliniken
Germany (DE)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Urologische Gemeinschaftspraxis / Urologie Pasing
Germany (DE)
Universitätsklinikum Freiburg
Germany (DE)
Centrum für Operative Urologie
Germany (DE)
Praxis für interdisziplinäre Onkologie & Hämatologie GbR
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Alfried Krupp Krankenhaus
Germany (DE)
St. Bonifatius Hospital
Germany (DE)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
Germany (DE)
HELIOS Kliniken
Germany (DE)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Urologische Gemeinschaftspraxis / Urologie Pasing
Germany (DE)
Universitätsklinikum Freiburg
Germany (DE)
Centrum für Operative Urologie
Germany (DE)
Praxis für interdisziplinäre Onkologie & Hämatologie GbR
Germany (DE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Alfried Krupp Krankenhaus
Germany (DE)
St. Bonifatius Hospital
Germany (DE)
Universitätsklinikum Schleswig-Holstein (UKSH)
Germany (DE)
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Germany (DE)
Universitätsklinikum Frankfurt am Main (KGU)
Germany (DE)
How to cite
APA:
Bergmann, L., Beck, J., Bothe, K., Brinkmann, O.A., Buse, S., Goebell, P.,... Gschwend, J.E. (2014). Treatment algorithm for metastatic renal cell carcinoma--recommendations based on evidence and clinical practice. Oncology Research and Treatment, 37(3), 136-41. https://dx.doi.org/10.1159/000360179
MLA:
Bergmann, Lothar, et al. "Treatment algorithm for metastatic renal cell carcinoma--recommendations based on evidence and clinical practice." Oncology Research and Treatment 37.3 (2014): 136-41.
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