Catalytic C - H amination with unactivated amines through copper(II) amides

Wiese S, Badiei YM, Gephart RT, Mossin S, Varonka MS, Melzer MM, Meyer K, Cundari TR, Warren TH (2010)

Publication Type: Journal article, Original article

Publication year: 2010

Journal

Angewandte Chemie International Edition Wiley

Original Authors: Wiese S., Badiei Y.M., Gephart R.T., Mossin S., Varonka M.S., Melzer M.M., Meyer K., Cundari T.R., Warren T.H.

Publisher: Wiley-VCH Verlag

Book Volume: 49

Pages Range: 8850-8855

Journal Issue: 47

DOI: 10.1002/anie.201003676

Abstract

En route to catalysis: Two equivalents of the three-coordinate copper(II) amide [(Cl NN)Cu]-NHAd participate in stoichiometric C - H amination by a H-atom abstraction/radical capture sequence. This active species may be generated through a copper(II) tert-butoxide intermediate to allow for the unprecedented catalytic amination of sp -C - H bonds with unactivated alkylamines. This method greatly expands the range of amines for catalytic C - H amination since most protocols require N-based electron-withdrawing groups. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Authors with CRIS profile

Karsten Meyer Lehrstuhl für Anorganische und Allgemeine Chemie

Involved external institutions

Georgetown University US United States (USA) (US) University of North Texas (UNT) US United States (USA) (US)

How to cite

APA:

Wiese, S., Badiei, Y.M., Gephart, R.T., Mossin, S., Varonka, M.S., Melzer, M.M.,... Warren, T.H. (2010). Catalytic C - H amination with unactivated amines through copper(II) amides. Angewandte Chemie International Edition, 49(47), 8850-8855. https://dx.doi.org/10.1002/anie.201003676

MLA:

Wiese, Stefan, et al. "Catalytic C - H amination with unactivated amines through copper(II) amides." Angewandte Chemie International Edition 49.47 (2010): 8850-8855.

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